Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release

Table 5

Drug content and weight variation of bisoprolol fumarate matrix tablets.

Formulation codes	Drug content; (%)^a	Weight variation; (%)^b
F-1	99.03 ± 0.59	2.12 ± 0.18
F-2	98.42 ± 0.72	2.25 ± 0.24
F-3	98.14 ± 0.65	3.04 ± 0.28
F-4	97.99 ± 0.85	3.07 ± 0.19
F-5	99.11 ± 1.22	2.31 ± 0.15
F-6	98.62 ± 0.52	1.90 ± 0.12
F-7	98.92 ± 0.78	2.02 ± 0.14
F-8	98.66 ± 0.55	1.92 ± 0.13
F-O	98.93 ± 0.72	1.88 ± 0.08

^aMean ± S.D., 𝑛 = 20; ^bcoefficient of weight variation (%) = standard deviation/mean weight × 100.