Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release

Table 6

Results of curve fitting of the in vitro bisoprolol release data from different bisoprolol fumarate matrix tablets.

Formulation code	Correlation coefficient (𝑅^2)				Release exponent (𝑛)
	Zero-order	First-order	Higuchi	Korsmeyer-Peppas
F-1	0.9744	0.9908	0.8279	0.9410	0.60
F-2	0.9698	0.9929	0.7067	0.9415	0.73
F-3	0.9467	0.9951	0.6842	0.8979	0.69
F-4	0.9710	0.9948	0.7286	0.9317	0.70
F-5	0.9632	0.9941	0.7060	0.9083	0.70
F-6	0.9566	0.9906	0.6924	0.9047	0.71
F-7	0.9673	0.9953	0.7058	0.9092	0.71
F-8	0.9650	0.9944	0.7212	0.9099	0.69
F-O	0.9733	0.9910	0.7111	0.9460	0.74