Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse

<table>Doxorubicin exacerbates ventricular dilation in adult erbB4-KO 
hearts. Hematoxilin-eosin stained longitudinal and transverse 
ventricular sections from doxorubicin-treated (a) 1-month young 
adult <i>erbB4</i>F/F:<i>MLC2v+/+</i> (WTD), and <i>erbB4</i>F/F:<i>MLC2v</i>-Cre+/− (erbB4-KOD) mice and (b) 
3-months adult WTD and erbB4-KOD mice display exacerbated 
ventricular dilation. Dilation of both RV and LV is noted in the 
doxorubicin-treated at the age of 1 month erbB4-KO hearts. 
Aggravated dilation was monitored at the age of 3 months. Scale 
bar: 1 mm.</table>

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Figure 1

Figure 1: Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse 