Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse

Table 1

Doxorubicin-mediated cardiomyocyte phenotypic modifications. Heart weight and body weight were monitored in WT, WTD, erbB4-KO, and KOD (n = 20) at 1 and 3 months of age. Hypertrophic growth is indicated by the increase in heart-body-weight ratio in erbB4-KO and KOD compared to WT and WTD. Cell length was determined in isolated cardiomyocytes from hearts of 1 and 3 months of age (n = 4). The length average was increased in young adult KOD. The average over 129 μm long was increased in KO, WTD, and KOD compared to WT hearts. Values are means ± SD; Data changes were statistically compared to WT, ^#P < 0.05; *P < 0.01.

Morphology	WT	KO	WTD	KOD
Young Adult (1 month)
Heart/Body weight (mg/g)	5.2 ± 0.4	5.3 ± 0.6	5.2 ± 0.5	6.2 ± 0.8^#
Body weight (g)	17.4 ± 2.0	17.3 ± 2.2	17.3 ± 2.0	17.2 ± 1.5
Average cell length > 90 μm	95 ± 10	102 ± 8	100 ± 4	137 ± 21^#
Adult (3 month)
Heart/Body weight (mg/g)	5.6 ± 0.6	7.3 ± 0.8*	5.4 ± 0.7	6.7 ± 0.8
Body weight (g)	30.1 ± 2.5	30.3 ± 2.2	29.4 ± 2.2	28.4 ± 2.2
Average cell length > 129 μm, (%)	152 ± 14 (15)	195 ± 50* (75)	174 ± 57^# (42)	208 ± 58* (65)

* P < 0.01, ^#P < 0.05.