Doxorubicin and NRG-1/erbB4-Deficiency Affect Gene Expression Profile: Involving Protein Homeostasis in Mouse

Table 4

Deregulation of ubiquitin-proteasome system genes. Comparative expression levels among the three models. Upregulation of Ubiquitin ligase, associated regulatory genes and deregulation of related proteases are significant in erbB4-KOD. Significant data correspond to fold change ratios at FDR < 10, ns: not significant.

Gene	Genebank	ErbB4-KO		WTD		ErbB4-KOD
		ratio	FDR	ratio	FDR	ratio	FDR
Ubiquitin-Proteasome system
Ubiquitin-conjugating enzyme 5 (Ubc5 homolog)	AA517487	1.1	ns	0.9	ns	5.6	0.5
Casitas B-lineage lymphoma b (Cblb)	AI430293	1.0	ns	1.8	0.9	2.2	2.1
Autophagy-related 4A-like (Atg4a homolog)	AI048074	0.9	ns	1.0	ns	2.0	0.2
LON peptidase (lonp)	AA241939	0.8	ns	1.6	9.1	2.0	0.5
Ubiquitin ligase complex component (Ubr)	AA615286	1.5	6.9	2.2	0.6	1.8	1.7
Carboxypeptidase X 2 M14 family (Cpxm2)	AA690480	1.4	ns	1.6	0.9	1.7	0.8
Ubiquitin-regulatory protein (Nsfl1c)	AW2095992	0.7	4.9	0.9	ns	1.5	0.7
Ubiquitin-like 1 (sentrin) activating enzyme subunit 1 (Sae1)	AI604685	1.0	ns	1.0	ns	0.6	2.5
Proteasome beta 9 (multifunctional protease 2) (Psmb9)	AA822485	1.0	ns	0.6	5.2	0.7	0.1

FDR: false discovery rate (%), FDR > 10 = not significant (ns).