Table of Contents
ISRN Oncology
Volume 2012 (2012), Article ID 746025, 10 pages
http://dx.doi.org/10.5402/2012/746025
Research Article

Adverse Cell Culture Conditions Mimicking the Tumor Microenvironment Upregulate ABCG2 to Mediate Multidrug Resistance and a More Malignant Phenotype

School of Pharmacy, The Chinese University of Hong Kong, Hong Kong

Received 7 February 2012; Accepted 1 March 2012

Academic Editors: S. Chakrabarty, P. Clavère, N. Fujimoto, and T. T. Trangas

Copyright © 2012 Grace M. Y. Cheng and Kenneth K. W. To. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. W. Robey, O. Polgar, J. Deeken, K. W. To, and S. E. Bates, “ABCG2: determining its relevance in clinical drug resistance,” Cancer and Metastasis Reviews, vol. 26, no. 1, pp. 39–57, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. D. D. Ross, J. E. Karp, T. T. Chen, and L. A. Doyle, “Expression of breast cancer resistance protein in blast cells from patients with acute leukemia,” Blood, vol. 96, no. 1, pp. 365–368, 2000. View at Google Scholar · View at Scopus
  3. P. Krishnamurthy, D. D. Ross, T. Nakanishi et al., “The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme,” The Journal of Biological Chemistry, vol. 279, no. 23, pp. 24218–24225, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Dean, T. Fojo, and S. Bates, “Tumour stem cells and drug resistance,” Nature Reviews Cancer, vol. 5, no. 4, pp. 275–284, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Vaupel, F. Kallinowski, and P. Okunieff, “Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review,” Cancer Research, vol. 49, no. 23, pp. 6449–6465, 1989. View at Google Scholar · View at Scopus
  6. M. R. Buchakjian and S. Kornbluth, “The engine driving the ship: metabolic steering of cell proliferation and death,” Nature Reviews Molecular Cell Biology, vol. 11, no. 10, pp. 715–727, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. W. H. Koppenol, P. L. Bounds, and C. V. Dang, “Otto Warburg's contributions to current concepts of cancer metabolism,” Nature Reviews Cancer, vol. 11, no. 5, pp. 325–337, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. R. A. Gatenby and R. J. Gillies, “A microenvironmental model of carcinogenesis,” Nature Reviews Cancer, vol. 8, no. 1, pp. 56–61, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Miyake, L. Mickley, T. Litman et al., “Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes,” Cancer Research, vol. 59, no. 1, pp. 8–13, 1999. View at Google Scholar · View at Scopus
  10. T. Knutsen, V. K. Rao, T. Ried et al., “Amplication of 4q21-q22 and the MXR gene in independently derived mitoxantrone-resistant cell lines,” Genes Chromosomes Cancer, vol. 27, no. 1, pp. 110–116, 2000. View at Google Scholar
  11. K. K. W. To, Z. Zhan, T. Litman, and S. E. Bates, “Regulation of ABCG2 expression at the 3′ untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line,” Molecular and Cellular Biology, vol. 28, no. 17, pp. 5147–5161, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Y. Ho, W. P. Tsang, S. K. Kong, and T. T. Kwok, “The critical role of caspases activation in hypoxia/reoxygenation induced apoptosis,” Biochemical and Biophysical Research Communications, vol. 345, no. 3, pp. 1131–1137, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. K. K. To, L. Yu, S. W. Liu, J. H. Fu, and C. H. Cho, “Constitutive AhR activation leads to concomitant ABCG2-mediated multidrug resistance in cisplatin-resistant esophageal carcinoma cells,” Molecular Carcinogenesis, vol. 51, no. 6, pp. 449–464, 2012. View at Publisher · View at Google Scholar
  14. K. K. To, O. Polgar, L. M. Huff, K. Morisaki, and S. E. Bates, “Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cells,” Molecular Cancer Research, vol. 6, no. 1, pp. 151–164, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Skehan, R. Storeng, D. Scudiero et al., “New colorimetric cytotoxicity assay for anticancer-drug screening,” Journal of the National Cancer Institute, vol. 82, no. 13, pp. 1107–1112, 1990. View at Google Scholar · View at Scopus
  16. T. L. Whiteside, “The tumor microenvironment and its role in promoting tumor growth,” Oncogene, vol. 27, no. 45, pp. 5904–5912, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Vaupel, F. Kallinowski, and P. Okunieff, “Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review,” Cancer Research, vol. 49, no. 23, pp. 6449–6465, 1989. View at Google Scholar · View at Scopus
  18. C. H. M. Versantvoort, H. J. Broxterman, J. Lankelma, N. Feller, and H. M. Pinedo, “Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells,” Biochemical Pharmacology, vol. 48, no. 6, pp. 1129–1136, 1994. View at Publisher · View at Google Scholar · View at Scopus
  19. R. H. Xu, H. Pelicano, Y. Zhou et al., “Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia,” Cancer Research, vol. 65, no. 2, pp. 613–621, 2005. View at Google Scholar · View at Scopus
  20. C. Lotz, D. K. Kelleher, B. Gassner, M. Gekle, P. Vaupel, and O. Thews, “Role of the tumor microenvironment in the activity and expression of the p-glycoprotein in human colon carcinoma cells,” Oncology reports, vol. 17, no. 1, pp. 239–244, 2007. View at Google Scholar · View at Scopus
  21. S. Barban and H. O. Schulze, “The effects of 2-deoxyglucose on the growth and metabolism of cultured human cells,” The Journal of Biological Chemistry, vol. 236, no. 7, pp. 1887–1889, 1961. View at Google Scholar
  22. M. Salas, E. Vinuela, and A. Sols, “Spontaneous and enzymatically catalyzed anomerization of glucose 6-phosphate and anomeric specificity of related enzymes,” The Journal of Biological Chemistry, vol. 240, no. 2, pp. 561–568, 1965. View at Google Scholar