Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet

Table 3

Litter size (n = 10–14 mothers per group), fetuses’ body weight (n = 46–70 fetuses from 6-7 mothers per group) and placenta weight (n = 12–20) obtained from different groups of mothers on Gd 20. Values means ± SEM.

	Litter size	Fetuses BW (grams)	Placenta weight (grams)	Fetuses BW: placental weight
ND	11.3 ± 0.51	3.49 ± 0.05	0.68 ± 0.05	4.73 ± 0.32
FRD	11.4 ± 0.62	3.68 ± 0.04^*	0.75 ± 0.08	6.39 ± 0.39^*
ND + MF	11.2 ± 0.53	3.36 ± 0.05^*	0.71 ± 0.02	4.85 ± 0.42
FRD + MF	10.2 ± 0.86	3.33 ± 0.03^*+	0.78 ± 0.06	4.65 ± 0.38^+
SUR + ND	10.3 ± 0.67	3.35 ± 0.04^*	0.66 ± 0.05	4.97 ± 0.46

^∗𝑃<0.05 versus ND values.
⁺𝑃<0.05 versus FRD values.