Table of Contents
ISRN Pharmacology
Volume 2012 (2012), Article ID 760484, 13 pages
http://dx.doi.org/10.5402/2012/760484
Review Article

Behcet's Disease: New Concepts in Cardiovascular Involvements and Future Direction for Treatment

Division of Rheumatology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Received 17 November 2011; Accepted 15 December 2011

Academic Editors: S. Ceruti and R. Fantozzi

Copyright © 2012 M. B. Owlia and G. Mehrpoor. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Gül, “Behçet's disease as an autoinflammatory disorder,” Current Drug Targets: Inflammation and Allergy, vol. 4, no. 1, pp. 81–83, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Yazici, H. Pazarli, and S. Yurdakul, “Influence of age of onset and patient's sex on the prevalence and severity of manifestations of Behcet's syndrome,” Annals of the Rheumatic Diseases, vol. 43, no. 6, pp. 783–789, 1984. View at Google Scholar
  3. C. C. Zouboulis, “Epidemiology of Adamantiades-Behcet's disease,” Annales de Medecine Interne, vol. 150, no. 6, pp. 488–498, 1999. View at Google Scholar · View at Scopus
  4. F. Erkan, A. Gül, and E. Tasali, “Pulmonary manifestations of Behçet's disease,” Thorax, vol. 56, no. 7, pp. 572–578, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. F. Davatchi, A. R. Jamshidi, A. T. Banihashemi et al., “WHO-ILAR COPCORD study (stage 1, urban study) in Iran,” Journal of Rheumatology, vol. 35, no. 7, pp. 1384–1390, 2008. View at Google Scholar · View at Scopus
  6. D. Mendes, M. Correia, M. Barbedo et al., “Behçet's disease—a contemporary review,” Journal of Autoimmunity, vol. 32, no. 3-4, pp. 178–188, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. T. Akpolat, Y. Koç, I. Yeniay et al., “Familial Behçet's disease,” The European journal of medicine, vol. 1, no. 7, pp. 391–395, 1992. View at Google Scholar · View at Scopus
  8. E. J. Chae, K. H. Do, J. B. Seo et al., “Radiologic and clinical findings of Behçet disease: comprehensive review of multisystemic involvement,” Radiographics, vol. 28, no. 5, p. e31, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. C. Mendoza-Pinto, M. García-Carrasco, M. Jiménez-Hernández et al., “Etiopathogenesis of Behcet's disease,” Autoimmunity Reviews, vol. 9, no. 4, pp. 241–245, 2010. View at Publisher · View at Google Scholar · View at PubMed
  10. I. Fresko, M. Soy, V. Hamuryudan et al., “Genetic anticipation in Behcet's syndrome,” Annals of the Rheumatic Diseases, vol. 57, no. 1, pp. 45–48, 1998. View at Google Scholar · View at Scopus
  11. G. Geri, B. Terrier, M. Rosenzwajg et al., “Critical role of IL-21 in modulating TH17 and regulatory T cells in Behet disease,” Journal of Allergy and Clinical Immunology, vol. 128, no. 3, pp. 655–664, 2011. View at Publisher · View at Google Scholar · View at PubMed
  12. Z. Touma, C. Farra, A. Hamdan et al., “TNF polymorphisms in patients with Behcet disease: a meta-analysis,” Archives of Medical Research, vol. 41, no. 2, pp. 142–146, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. M. Bonyadi, Z. Jahanafrooz, M. Esmaeili et al., “TNF-α gene polymorphisms in Iranian Azeri Turkish patients with Behcet's Disease,” Rheumatology International, vol. 30, no. 2, pp. 285–289, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. A. Akman, N. Sallakci, H. Kacaroglu et al., “Relationship between periodontal findings and the TNF-α Gene 1031T/C polymorphism in Turkish patients with Behçet's disease,” Journal of the European Academy of Dermatology and Venereology, vol. 22, no. 8, pp. 950–957, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. I. Krause and A. Weinberger, “Behçet's disease,” Current Opinion in Rheumatology, vol. 20, no. 1, pp. 82–87, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. M. Kamoun, H. Chelbi, M. H. Houman, J. Lacheb, and K. Hamzaoui, “Tumor necrosis factor gene polymorphisms in Tunisian patients with Behçet's disease,” Human Immunology, vol. 68, no. 3, pp. 201–205, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. A. Akman, N. Sallakci, M. Coskun et al., “TNF-α gene 1031 T/C polymorphism in Turkish patients with Behçet's disease,” British Journal of Dermatology, vol. 155, no. 2, pp. 350–356, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. R. X. Leng, G. M. Chen, H. F. Pan, and D. Q. Ye, “The role of IL-23/IL-17 axis in the etiopathogenesis of Behçet's disease,” Clinical rheumatology, vol. 29, no. 10, p. 1209, 2010. View at Google Scholar
  19. N. S. Ekinci, E. Alpsoy, A. A. Karakas, S. B. Yilmaz, and O. Yegin, “IL-17A has an important role in the acute attacks of behçet's disease,” Journal of Investigative Dermatology, vol. 130, no. 8, pp. 2136–2138, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. F. Kaneko, A. Togashi, S. Saito et al., “Behçet's disease (Adamantiades-Behçet's disease),” Clinical and Developmental Immunology, vol. 2011, Article ID 681956, 7 pages, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. G. Mumcu, N. Inanc, S. Yavuz, and H. Direskeneli, “The role of infectious agents in the pathogenesis, clinical manifestations and treatment strategies in Behçet's disease,” Clinical and Experimental Rheumatology, vol. 25, no. 4, pp. S27–S33, 2007. View at Google Scholar · View at Scopus
  22. M. M. Al-Waiz, K. E. Sharquie, M. H. A-Qaissi, and R. K. Hayani, “Colchicine and benzathine penicillin in the treatment of Behçet disease: a case comparative study,” Dermatology Online Journal, vol. 11, no. 3, article no. 3, 2005. View at Google Scholar · View at Scopus
  23. H. Demiroglu, O. I. Özcebe, I. Barista, S. Dündar, and B. Eldem, “Interferon alfa-2b, colchicine, and benzathine penicillin versus colchicine and benzathine penicillin in Behcet's disease: a randomised trial,” Lancet, vol. 355, no. 9204, pp. 605–609, 2000. View at Google Scholar · View at Scopus
  24. M. Çalgüneri, S. Kiraz, I. Ertenli, M. Benekli, Y. Karaarslan, and I. Çelik, “The effect of prophylactic penicillin treatment on the course of arthritis episodes in patients with Behçet's disease: a randomized clinical trial,” Arthritis and Rheumatism, vol. 39, no. 12, pp. 2062–2065, 1996. View at Google Scholar
  25. M. La Regina, F. Orlandini, D. Prisco, and F. Dentali, “Homocysteine in vascular behçet disease: a meta-analysis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 10, pp. 2067–2074, 2010. View at Publisher · View at Google Scholar · View at PubMed
  26. J. Shanker, A. Y. Gasparyan, G. D. Kitas, and V. V. Kakkar, “Platelet function and antiplatelet therapy in cardiovascular disease: implications of genetic polymorphisms,” Current Vascular Pharmacology, vol. 9, no. 4, pp. 479–489, 2011. View at Publisher · View at Google Scholar
  27. A. Y. Gasparyan, L. Ayvazyan, D. P. Mikhailidis, and G. D. Kitas, “Mean platelet volume: a link between thrombosis and inflammation?” Current Pharmaceutical Design, vol. 17, no. 1, pp. 47–58, 2011. View at Publisher · View at Google Scholar
  28. H. Belguendouz, D. Messaoudène, K. Lahmar et al., “Interferon-γ and nitric oxide production during Behçet uveitis: immunomodulatory effect of interleukin-10,” Journal of Interferon and Cytokine Research, vol. 31, no. 9, pp. 643–651, 2011. View at Publisher · View at Google Scholar · View at PubMed
  29. K. Hamzaoui, I. B. Dhifallah, E. Karray, F. H. Sassi, and A. Hamzaoui, “Vitamin D modulates peripheral immunity in patients with Behçet's disease,” Clinical and Experimental Rheumatology, vol. 28, no. 4, pp. S50–S57, 2010. View at Google Scholar · View at Scopus
  30. D. Köhler, A. Straub, T. Weissmüller et al., “Phosphorylation of vasodilator-stimulated phosphoprotein prevents platelet-neutrophil complex formation and dampens myocardial ischemia-reperfusion injury,” Circulation, vol. 123, no. 22, pp. 2579–2590, 2011. View at Publisher · View at Google Scholar · View at PubMed
  31. G. E. Pamuk, Ö. N. Pamuk, H. Örüm, M. Demir, B. Turgut, and N. Çakir, “Might platelet-leucocyte complexes be playing a role in major vascular involvement of Behçet's disease? A comparative study,” Blood Coagulation and Fibrinolysis, vol. 21, no. 2, pp. 113–117, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. G. E. Pamuk, B. Turgut, Ö. N. Pamuk, Ö. Vural, M. Demir, and N. Çakr, “Increased circulating platelet-leucocyte complexes in patients with primary Raynaud's phenomenon and Raynaud's phenomenon secondary to systemic sclerosis: a comparative study,” Blood Coagulation and Fibrinolysis, vol. 18, no. 4, pp. 297–302, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. A. Zarbock, K. Singbartl, and K. Ley, “Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation,” Journal of Clinical Investigation, vol. 116, no. 12, pp. 3211–3219, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. D. T. Ertugrul, A. Gürsoy, M. Yücel et al., “Effects of raloxifene on platelet functions in patients with postmenopausal osteoporosis,” Platelets, vol. 17, no. 6, pp. 351–353, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. D. J. H. McCabe, P. Harrison, I. J. Mackie et al., “Increased platelet count and leucocyte-platelet complex formation in acute symptomatic compared with asymptomatic severe carotid stenosis,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 76, no. 9, pp. 1249–1254, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. B. C. Van Bussel, F. Schouten, R. M. Henry et al., “Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period,” Hypertension, vol. 58, no. 4, pp. 588–595, 2011. View at Publisher · View at Google Scholar · View at PubMed
  37. J. A. Clayton, D. Chalothorn, and J. E. Faber, “Vascular endothelial growth factor-a specifies formation of native collaterals and regulates collateral growth in ischemia,” Circulation Research, vol. 103, no. 9, pp. 1027–1036, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. E. Bozoglu, A. Dinc, H. Erdem, S. Pay, I. Simsek, and I. H. Kocar, “Vascular endothelial growth factor and monocyte chemoattractant protein-1 in Behçet's patients with venous thrombosis,” Clinical and Experimental Rheumatology, vol. 23, no. 4, pp. S42–S48, 2005. View at Google Scholar · View at Scopus
  39. K. W. Lee, G. Y. H. Lip, and A. D. Blann, “Plasma angiopoietin-1, angiopoietin-2, angiopoietin receptor Tie-2, and vascular endothelial growth factor levels in acute coronary syndromes,” Circulation, vol. 110, no. 16, pp. 2355–2360, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. Y. Turkoz, C. Evereklioglu, A. Özkiriş et al., “Serum levels of soluble P-selectin are increased and associated with disease activity in patients with Behçet's syndrome,” Mediators of Inflammation, vol. 2005, no. 4, pp. 237–241, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. R. A. Sari, A. Kiziltunç, S. Taysý, S. Akdemýr, and M. Gündoǧdu, “Levels of soluble E-selectin in patients with active Behçet's disease,” Clinical Rheumatology, vol. 24, no. 1, pp. 55–59, 2005. View at Publisher · View at Google Scholar · View at PubMed
  42. S. E. Tunc, K. Aksu, G. Keser et al., “Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients,” Rheumatology International, vol. 25, no. 5, pp. 326–331, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  43. S. Haznedaroǧlu, Y. Karaaslan, Y. Büyükaşik et al., “Selectin adhesion molecules in Behcet's disease,” Annals of the Rheumatic Diseases, vol. 59, no. 1, pp. 61–63, 2000. View at Publisher · View at Google Scholar
  44. G. Triolo, A. Accardo-Palumbo, G. Triolo, M. C. Carbone, A. Ferrante, and E. Giardina, “Enhancement of endothelial cell E-selectin expression by sera from patients with active Behcet's disease: moderate correlation with anti- endothelial cell antibodies and serum myeloperoxidase levels,” Clinical Immunology, vol. 91, no. 3, pp. 330–337, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  45. F. Batioǧlu, L. S. Atmaca, H. G. Karabulut, and D. B. Sayin, “Factor V Leiden and prothrombin gene G20210A mutations in ocular Behçet disease,” Acta Ophthalmologica Scandinavica, vol. 81, no. 3, pp. 283–285, 2003. View at Publisher · View at Google Scholar
  46. A. Gurgey, G. Balta, and A. Boyvat, “Factor V Leiden mutation and PAI-1 gene 4G/5G genotype in thrombotic patients with Behcet's disease,” Blood Coagulation and Fibrinolysis, vol. 14, no. 2, pp. 121–124, 2003. View at Publisher · View at Google Scholar · View at Scopus
  47. L. Mammo, A. Al-Dalaan, S. S. Bahabri, and J. N. Saour, “Association of factor V Leiden with Behcet's disease,” Journal of Rheumatology, vol. 24, no. 11, pp. 2196–2198, 1997. View at Google Scholar · View at Scopus
  48. A. Gül, U. Özbek, C. Öztürk, M. Inanç, M. Koniçe, and T. Özcelik, “Coagulation factor V gene mutation increases the risk of venous thrombosis in Behcet's disease,” British Journal of Rheumatology, vol. 35, no. 11, pp. 1178–1180, 1996. View at Google Scholar
  49. R. Mader, Z. Michael, M. Adawi, R. Mader, and I. Lavi, “Thrombophilic factors and their relation to thromboembolic and other clinical manifestations in Behcet's disease,” Journal of Rheumatology, vol. 26, no. 11, pp. 2404–2408, 1999. View at Google Scholar · View at Scopus
  50. N. Lenk, G. Özet, N. Alli, Ö. Çoban, and S. Erbaşi, “Protein C and protein S activities in Behcet's disease as risk factors of thrombosis,” International Journal of Dermatology, vol. 37, no. 2, pp. 124–125, 1998. View at Publisher · View at Google Scholar
  51. F. Shahram, A. Faridar, M. G. Hamedani et al., “Plasma homocysteine level in patients with Behcet's disease with or without thrombosis,” Archives of Iranian Medicine, vol. 13, no. 6, pp. 476–481, 2010. View at Google Scholar · View at Scopus
  52. K. Aksu, N. Turgan, F. Oksel et al., “Hyperhomocysteinaemia in Behçet's disease,” Rheumatology, vol. 40, no. 6, pp. 687–690, 2001. View at Google Scholar
  53. S. Demirer, N. Şengül, M. A. Yerdel et al., “Haemostasis in patients with Behcet's disease,” European Journal of Vascular and Endovascular Surgery, vol. 19, no. 6, pp. 570–574, 2000. View at Publisher · View at Google Scholar · View at PubMed
  54. S. Esmat, H. El Sherif, S. Anwar, I. Fahmy, M. Elmenyawi, and O. Shaker, “Lipoprotein (a) and nitrites in Behcet's disease: relationship with disease activity and vascular complictions,” European Journal of Dermatology, vol. 16, no. 1, pp. 67–71, 2006. View at Google Scholar · View at Scopus
  55. Ö. Gürbüz, Y. Özdemir, C. B. Coşar, and G. Kural, “Lipoprotein (a) in Behçet's disease as an indicator of disease activity and in thrombotic complications,” European Journal of Ophthalmology, vol. 11, no. 1, pp. 62–65, 2001. View at Google Scholar
  56. S. Tokay, H. Direskeneli, S. Yurdakul, and T. Akoglu, “Anticardiolipin antibodies in Behçet's disease: a reassessment,” Rheumatology, vol. 40, no. 2, pp. 192–195, 2001. View at Google Scholar · View at Scopus
  57. A. N. Al-Dalaan, S. R. Al-Ballaa, M. A. Al-Janadi, S. Bohlega, and S. Bahabri, “Association of anti-cardiolipin antibodies with vascular thrombosis and neurological manifestation of Behcet's disease,” Clinical Rheumatology, vol. 12, no. 1, pp. 28–30, 1993. View at Google Scholar · View at Scopus
  58. M. Zivkovic, M. Zlatanovic, G. Zlatanovic, J. Djordjevic-Jocic, and S. Cekic, “Anticardiolipin antibodies in patients with Behcet's disease,” Bosnian Journal of Basic Medical Sciences, vol. 11, no. 1, pp. 58–61, 2011. View at Google Scholar
  59. S. Yurdakul and H. Yazici, “Behçet's syndrome,” Best Practice and Research: Clinical Rheumatology, vol. 22, no. 5, pp. 793–809, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  60. N. Acikgoz, Y. Karincaoglu, N. Ermis et al., “Increased mean platelet volume in Behçet's disease with thrombotic tendency,” The Tohoku journal of experimental medicine, vol. 221, no. 2, pp. 119–123, 2010. View at Publisher · View at Google Scholar · View at Scopus
  61. Y. Park, N. Schoene, and W. Harris, “Mean platelet volume as an indicator of platelet activation: methodological issues,” Platelets, vol. 13, no. 5-6, pp. 301–306, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  62. S. Kamath, A. D. Blann, and G. Y. H. Lip, “Platelet activation: assessment and quantification,” European Heart Journal, vol. 22, no. 17, pp. 1561–1571, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  63. A. Y. Gasparyan, A. Stavropoulos-Kalinoglou, D. P. Mikhailidis, T. E. Toms, K. M. J. Douglas, and G. D. Kitas, “The rationale for comparative studies of accelerated atherosclerosis in rheumatic diseases,” Current Vascular Pharmacology, vol. 8, no. 4, pp. 437–449, 2010. View at Publisher · View at Google Scholar · View at Scopus
  64. E. Seyahi, S. Ugurlu, R. Cumali et al., “Atherosclerosis in Behçet's syndrome,” Seminars in Arthritis and Rheumatism, vol. 38, no. 1, pp. 1–12, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  65. M. A. Öztürk, S. Ünverdi, S. O. Oktar et al., “Vascular endothelial growth factor and carotid intima-media thickness in patients with Behç's disease,” Clinical Rheumatology, vol. 27, no. 8, pp. 961–966, 2008. View at Publisher · View at Google Scholar · View at PubMed
  66. S. N. Hong, J. C. Park, N. S. Yoon et al., “Carotid artery intima-media thickness in Behcet's disease patients without significant cardiovascular involvement,” Korean Journal of Internal Medicine, vol. 23, no. 2, pp. 87–93, 2008. View at Publisher · View at Google Scholar · View at Scopus
  67. M. Marzban, M. H. Mandegar, A. Karimi et al., “Cardiac and great vessel involvement in ‘Behcet's disease’,” Journal of Cardiac Surgery, vol. 23, no. 6, pp. 765–768, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  68. Y. Sezen, H. Buyukatipoglu, Z. Kucukdurmaz, and R. Geyik, “Cardiovascular involvement in Behçet's disease,” Clinical Rheumatology, vol. 29, no. 1, pp. 7–12, 2010. View at Publisher · View at Google Scholar · View at PubMed
  69. B. Wechsler, L. T. H. Du, and E. Kieffer, “Cardiovascular manifestations of Behcet's disease,” Annales de Medecine Interne, vol. 150, no. 7, pp. 542–554, 1999. View at Google Scholar · View at Scopus
  70. S. Lakhanpal, K. Tani, and J. T. Lie, “Pathologic features of Behcet's syndrome: a review of Japanese autopsy registry data,” Human Pathology, vol. 16, no. 8, pp. 790–795, 1985. View at Google Scholar
  71. C. Nojiri, M. Endo, and H. Koyanagi, “Conduction disturbance in Behcet's disease. Association with ruptured aneurysm of the sinus of Valsalva into the left ventricular cavity,” Chest, vol. 86, no. 4, pp. 636–638, 1984. View at Google Scholar · View at Scopus
  72. C. M. Kwon, S. H. Lee, J. H. Kim et al., “A case of Behçet's disease with pericarditis, thrombotic thrombocytopenic purpura, deep vein thrombosis and coronary artery pseudo aneurysm,” Korean Journal of Internal Medicine, vol. 21, no. 1, pp. 50–56, 2006. View at Google Scholar · View at Scopus
  73. B. Ökcun, T. Baran, E. Babalik, and S. Kücükoglu, “Multichamber masses and constrictive pericarditis in Behçet's disease,” Clinical and Experimental Rheumatology, vol. 21, no. 4, supplement 30, p. S55, 2003. View at Google Scholar
  74. G. Vaiopoulos, G. Stamatelos, A. Aessopos, S. Michael, G. Christopoulos, and P. Kaklamanis, “Asymptomatic pericarditis in Adamantiadis-Behcet's disease,” Clinical and Experimental Rheumatology, vol. 13, no. 5, pp. 649–651, 1995. View at Google Scholar · View at Scopus
  75. J. Lanfranchi, M. Robineau, P. Delaporte, R. N. Sachs, and J. Salama, “Acute pericarditis and Behçet's disease,” La Nouvelle presse medicale, vol. 10, no. 24, pp. 2038–2039, 1981. View at Google Scholar · View at Scopus
  76. G. E. Pineda, S. Khanal, M. Mandawat, and J. Wilkin, “Large atherosclerotic left main coronary aneurysm—a case report and review of the literature,” Angiology, vol. 52, no. 7, pp. 501–504, 2001. View at Google Scholar · View at Scopus
  77. D. Ioakimidis, C. Georganas, C. Panagoulis et al., “A case of Adamantiadis-Behcet's syndrome presenting as myocardial infarction,” Clinical and Experimental Rheumatology, vol. 11, no. 2, pp. 183–186, 1993. View at Google Scholar · View at Scopus
  78. H. Bardakci, U. Kervan, E. Boysan, L. Birincioglu, and A. Cobanoglu, “Aortic arch aneurysm, pseudocoarctation, and coronary artery disease: in a patient with Behçet's syndrome,” Texas Heart Institute Journal, vol. 34, no. 3, pp. 363–365, 2007. View at Google Scholar · View at Scopus
  79. M. H. Song, T. Watanabe, and H. Nakamura, “Successful off-pump coronary artery bypass for Behcet's disease,” Annals of Thoracic Surgery, vol. 77, no. 4, pp. 1451–1454, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  80. J. Zhuang, S. Wang, Z. Zhang, S. Zeng, Y. Shi, and S. Nong, “Acute myocardial infarction and ascending aortic aneurysm in a child with Behçet's disease,” Turkish Journal of Pediatrics, vol. 50, no. 1, pp. 81–85, 2008. View at Google Scholar · View at Scopus
  81. Ş. Türkölmez, N. Gökçora, M. Alkan, and M. Ali Gürer, “Evaluation of myocardial perfusion in patients with Behçet's disease,” Annals of Nuclear Medicine, vol. 19, no. 3, pp. 201–206, 2005. View at Google Scholar
  82. I. H. Güllü, M. Benekli, H. Müderrisoğlu et al., “Silent myocardial ischemia in Behçet's disease,” Journal of Rheumatology, vol. 23, no. 2, pp. 323–327, 1996. View at Google Scholar
  83. M. Fekih, S. Fennira, L. Ghodbane, and R. M. Zaouali, “Intracardiac thrombosis: unusual complication of Behcet's disease,” La Tunisie Médicale, vol. 82, no. 8, pp. 785–790, 2004. View at Google Scholar
  84. A. Vivante, Y. Bujanover, J. Jacobson, S. Padeh, and Y. Berkun, “Intracardiac thrombus and pulmonary aneurysms in an adolescent with Behçet disease,” Rheumatology International, vol. 29, no. 5, pp. 575–577, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  85. G. Vanhaleweyk, K. M. El-Ramahi, M. Hazmi, J. O. Sieck, L. Zaman, and M. Fawy, “Right atrial, right ventricular and left ventricular thrombi in (incomplete) Behcet's disease,” European Heart Journal, vol. 11, no. 10, pp. 957–959, 1990. View at Google Scholar · View at Scopus
  86. N. Mogulkoc, M. I. Burgess, and P. W. Bishop, “Intracardiac thrombus in Behcet's disease: a systematic review,” Chest, vol. 118, no. 2, pp. 479–487, 2000. View at Google Scholar · View at Scopus
  87. F. Atzeni, P. Sarzi-Puttini, A. Doria, L. Boiardi, N. Pipitone, and C. Salvarani, “Behçet's disease and cardiovascular involvement,” Lupus, vol. 14, no. 9, pp. 723–726, 2005. View at Publisher · View at Google Scholar · View at Scopus
  88. M. Elqatni, Y. Sekkach, A. Abouzahir, and D. Ghafir, “Right atrium thrombus and pulmonary artery aneurysm in a man with behçet's disease,” Internal Medicine, vol. 50, no. 3, pp. 263–264, 2011. View at Publisher · View at Google Scholar
  89. I. Dincer, R. Dandachi, Y. Atmaca, C. Erol, N. Caglar, and D. Oral, “A recurrent right heart thrombus in a patient with Behçet's disease,” Echocardiography, vol. 18, no. 1, pp. 15–18, 2001. View at Google Scholar · View at Scopus
  90. I. Ben Ghorbel, Z. Ibn Elhadj, M. Khanfir et al., “Intracardiac thrombus in Behçet's disease. A report of three cases,” Journal des Maladies Vasculaires, vol. 29, no. 3, pp. 159–161, 2004. View at Google Scholar · View at Scopus
  91. A. G. Sayin, F. S. Vural, A. K. Bozkurt, B. Oz, and N. Uygun, “Right atrial thrombus mimicking myxoma and bilateral pulmonary artery aneurysms in a patient with Behcet's disease—a case report,” Angiology, vol. 44, no. 11, pp. 915–918, 1993. View at Google Scholar · View at Scopus
  92. S. Hammami, S. Mahjoub, K. Ben-Hamda, R. Brahem, H. Gamra, and M. B. Farhat, “Intracardiac thrombus in Behçet's disease: two case reports,” Thrombosis Journal, vol. 3, article no. 9, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  93. D. Özatli, T. Kav, I. C. Haznedaroǧlu et al., “Cardiac and great vessel thrombosis in Behçet's disease,” Internal Medicine, vol. 40, no. 1, pp. 68–72, 2001. View at Google Scholar
  94. F. Atalay, D. Ernam, F. Ökten, and N. Akar, “Elevated FVIII and FIX level in a Behçet's disease patient with intracardiac thrombosis and pulmonary arterial aneurysms,” Thrombosis Research, vol. 115, no. 1-2, pp. 159–161, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  95. M. Cemri, A. Erkan, M. Ozdemir, and A. Cengel, “Behcet's disease with a large and free right atrial thrombus,” European Journal of Echocardiography, vol. 3, no. 3, pp. 233–235, 2002. View at Publisher · View at Google Scholar · View at Scopus
  96. M. Baykan, S. Celik, C. Erdöl et al., “Behçet's disease with a large intracardiac thrombus: a case report,” Heart, vol. 85, no. 4, article E7, 2001. View at Google Scholar · View at Scopus
  97. C. Gürgün, E. Ercan, C. Ceyhan et al., “Cardiovascular involvement in Behçet's disease,” Japanese Heart Journal, vol. 43, no. 4, pp. 389–398, 2002. View at Publisher · View at Google Scholar · View at Scopus
  98. K. Okada, K. Eishi, Y. Kitoh et al., “Huge aneurysm of the sinus of valsalva following infective endocarditis in Behcet's disease,” Journal of Heart Valve Disease, vol. 6, no. 2, pp. 179–180, 1997. View at Google Scholar · View at Scopus
  99. D. L. Huong, B. Wechsler, T. Papo et al., “Endomyocardial fibrosis in Behcet's disease,” Annals of the Rheumatic Diseases, vol. 56, no. 3, pp. 205–208, 1997. View at Google Scholar · View at Scopus
  100. N. K. Eryol, R. Topsakal, A. Abaci, and A. Oǧuzhan, “A case of atrioventricular complete block due to Behçet's disease,” Japanese heart journal, vol. 43, no. 6, pp. 697–701, 2002. View at Google Scholar · View at Scopus
  101. O. Kirimli, O. Aslan, O. Göldeli et al., “Heart rate variability, late potentials and QT dispersion as markers of myocardial involvement in patients with Behcet's disease,” Canadian Journal of Cardiology, vol. 16, no. 3, pp. 345–351, 2000. View at Google Scholar
  102. R. Sarica-Kucukoglu, A. Akdag-Kose, M. Kayabali et al., “Vascular involvement in Behçet's disease: a retrospective analysis of 2319 cases,” International Journal of Dermatology, vol. 45, no. 8, pp. 919–921, 2006. View at Publisher · View at Google Scholar · View at PubMed
  103. N. Düzgün, A. Ateş, O. T. Aydintuǧ, Ö. Demir, and Ü. Ölmez, “Characteristics of vascular involvement in Behçet's disease,” Scandinavian Journal of Rheumatology, vol. 35, no. 1, pp. 65–68, 2006. View at Publisher · View at Google Scholar · View at PubMed
  104. P. R. J. Ames, A. Steuer, A. Pap, and A. M. Denman, “Thrombosis in Behçet's disease: a retrospective survey from a single UK centre,” Rheumatology, vol. 40, no. 6, pp. 652–655, 2001. View at Google Scholar · View at Scopus
  105. A. Gürler, A. Boyvat, and Ü. Türsen, “Clinical manifestations of Behçet's disease: an analysis of 2147 patients,” Yonsei Medical Journal, vol. 38, no. 6, pp. 423–427, 1997. View at Google Scholar
  106. A. N. Al-Dalaan, S. R. Al Balaa, K. El Ramahi et al., “Behcet's disease in Saudi Arabia,” Journal of Rheumatology, vol. 21, no. 4, pp. 658–661, 1994. View at Google Scholar · View at Scopus
  107. Y. Koc, I. Gullu, G. Akpek et al., “Vascular involvement in Behcet's disease,” Journal of Rheumatology, vol. 19, no. 3, pp. 402–410, 1992. View at Google Scholar · View at Scopus
  108. E. Seyahi and S. Yurdakul, “Behcet's syndrome and thrombosis,” Mediterranean Journal of Hematology and Infectious Diseases, vol. 3, no. 1, Article ID e2011026, 2011. View at Google Scholar
  109. E. Kural-Seyahi, I. Fresko, N. Seyahi et al., “The long-term mortality and morbidity of Behçet syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center,” Medicine, vol. 82, no. 1, pp. 60–76, 2003. View at Publisher · View at Google Scholar
  110. G. Tomasson, P. A. Monach, and P. A. Merkel, “Thromboembolic disease in vasculitis,” Current Opinion in Rheumatology, vol. 21, no. 1, pp. 41–46, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  111. R. T. Walker, A. B. Woodyer, and J. A. Dormandy, “Venous claudication. A report of 15 cases and a review of the literature,” International Angiology, vol. 4, no. 3, pp. 365–367, 1985. View at Google Scholar · View at Scopus
  112. U. Alpagut, M. Ugurlucan, and E. Dayioglu, “Major arterial involvement and review of Behcet's disease,” Annals of Vascular Surgery, vol. 21, no. 2, pp. 232–239, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  113. A. Siva and S. Saip, “The spectrum of nervous system involvement in Behçet's syndrome and its differential diagnosis,” Journal of Neurology, vol. 256, no. 4, pp. 513–529, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  114. G. Hatemi, A. Silman, D. Bang et al., “EULAR recommendations for the management of Behçet disease,” Annals of the Rheumatic Diseases, vol. 67, no. 12, pp. 1656–1662, 2008. View at Publisher · View at Google Scholar · View at PubMed
  115. D. Saadoun, B. Wechsler, M. Resche-Rigon et al., “Cerebral venous thrombosis in Behçet's disease,” Arthritis Care and Research, vol. 61, no. 4, pp. 518–526, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  116. H. Yazici and I. Fresko, “Behçet's disease and other autoinflammatory conditions: what's in a name?” Clinical and Experimental Rheumatology, vol. 23, no. 4, supplement 38, pp. S1–S2, 2005. View at Google Scholar
  117. A. Siva, O. H. Kantarci, S. Saip et al., “Behçet's disease: diagnostic and prognostic aspects of neurological involvement,” Journal of Neurology, vol. 248, no. 2, pp. 95–103, 2001. View at Publisher · View at Google Scholar · View at Scopus
  118. G. Akman-Demir, P. Serdaroglu, and B. Tasçi, “Clinical patterns of neurological involvement in Behcet's disease: evaluation of 200 patients,” Brain, vol. 122, no. 11, pp. 2171–2181, 1999. View at Publisher · View at Google Scholar
  119. B. Wechsler, L. T. Du, and J. C. Piette, “Behçet's disease,” The European journal of medicine, vol. 1, no. 7, pp. 387–390, 1992. View at Google Scholar
  120. D. Aguiar de Sousa, T. Mestre, and J. M. Ferro, “Cerebral venous thrombosis in Behçet's disease: a systematic review,” Journal of Neurology, vol. 258, no. 5, pp. 719–727, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  121. I. Krause, L. Leibovici, D. Guedj, Y. Molad, Y. Uziel, and A. Weinberger, “Disease patterns of patients with Behcet's disease demonstrated by factor analysis,” Clinical and Experimental Rheumatology, vol. 17, no. 3, pp. 347–350, 1999. View at Google Scholar · View at Scopus
  122. S. Ketari Jamoussi, H. Chaaba, B. Ben Dhaou et al., “Arterial involvement in Behcet's disease: a series of 7 cases,” Tunisie Medicale, vol. 87, no. 9, pp. 583–588, 2009. View at Google Scholar · View at Scopus
  123. N. Kojima, Y. Sakano, S.-I. Ohki, and Y. Misawa, “Rapidly growing aortic arch aneurysm in Behçet's disease,” Interactive Cardiovascular and Thoracic Surgery, vol. 12, no. 3, pp. 502–504, 2011. View at Publisher · View at Google Scholar · View at PubMed
  124. K. Spiliotopoulos, B. Yanagawa, A. Crean, C. Overgaard, and S. J. Brister, “Surgical management of a left anterior descending pseudoaneurysm related to Behcet's disease,” Annals of Thoracic Surgery, vol. 91, no. 3, pp. 912–914, 2011. View at Publisher · View at Google Scholar · View at PubMed
  125. J. V. Rico, F. G. Pedrajas, I. C. González, and R. J. Segura Iglesias, “Urgent endovascular treatment of a ruptured tibioperoneal pseudoaneurysm in Behet's disease,” Annals of Vascular Surgery, vol. 25, no. 3, pp. 385.e11–385.e14, 2011. View at Publisher · View at Google Scholar · View at PubMed
  126. B. W. Ullery, A. Pochettino, G. J. Wang, B. M. Jackson, R. M. Fairman, and E. Y. Woo, “Celiac artery aneurysm repair in Behçet disease complicated by recurrent thoracoabdominal aortic aneurysms,” Vascular and Endovascular Surgery, vol. 44, no. 2, pp. 146–149, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  127. B. Kisacik, T. Kasifoglu, S. Akay et al., “Ulnar artery aneurysm in a patient with Behçet's disease,” Rheumatology International, vol. 30, no. 3, pp. 383–385, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  128. A. Yildirim, A. Isik, and S. Koca, “Subclavian artery pseudoaneurysm in Behcet's disease,” Clinical Rheumatology, vol. 26, no. 7, pp. 1151–1154, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  129. S. Men, M. N. Ozmen, F. Balkanci, S. Boyacigil, and H. Akbari, “Superior mesenteric artery aneurysm in Behcet's disease,” Abdominal Imaging, vol. 19, no. 4, pp. 333–334, 1994. View at Google Scholar · View at Scopus
  130. O. Uzun, T. Akpolat, and L. Erkan, “Pulmonary vasculitis in Behçet disease: a cumulative analysis,” Chest, vol. 127, no. 6, pp. 2243–2253, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  131. S. Benamour, B. Zeroual, R. Bennis, A. Amraoui, and S. Bettal, “Behcet's disease. 316 Cases,” Presse Medicale, vol. 19, no. 32, pp. 1485–1489, 1990. View at Google Scholar · View at Scopus
  132. S. Pay, T. Abbasov, H. Erdem et al., “Serum MMP-2 and MMP-9 in patients with Behçet's disease: Do their higher levels correlate to vasculo-Behçet's disease associated with aneurysm formation?” Clinical and Experimental Rheumatology, vol. 25, no. 4 SUPPL. 45, pp. S70–S75, 2007. View at Google Scholar
  133. H. Yazici, I. Fresko, and S. Yurdakul, “Behçet's syndrome: disease manifestations, management, and advances in treatment,” Nature Clinical Practice Rheumatology, vol. 3, no. 3, pp. 148–155, 2007. View at Publisher · View at Google Scholar · View at PubMed
  134. K. T. Calamia, M. Schirmer, and M. Melikoglu, “Major vessel involvement in Behçet's disease: an update,” Current Opinion in Rheumatology, vol. 23, no. 1, pp. 24–31, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  135. A. Gul, “Standard and novel therapeutic approaches to Behçet's disease,” Drugs, vol. 67, no. 14, pp. 2013–2022, 2007. View at Google Scholar · View at Scopus
  136. H. Yazici, H. Pazarli, C. G. Barnes et al., “A controlled trial OF azathioprine in Behcet's syndrome,” New England Journal of Medicine, vol. 322, no. 5, pp. 281–285, 1990. View at Google Scholar · View at Scopus
  137. V. Hamuryudan, Y. Özyazgan, N. Hizli et al., “Azathioprine in Behcet's syndrome: effects on long-term prognosis,” Arthritis and Rheumatism, vol. 40, no. 4, pp. 769–774, 1997. View at Publisher · View at Google Scholar
  138. D. Saadoun, B. Wechsler, C. Terrada et al., “Azathioprine in severe uveitis of Behçet's disease,” Arthritis Care & Research, vol. 62, no. 12, pp. 1733–1738, 2010. View at Google Scholar
  139. P. A. Pacheco, S. R. J. Taylor, M. T. Cuchacovich, and G. V. Diaz, “Azathioprine in the management of autoimmune uveitis,” Ocular Immunology and Inflammation, vol. 16, no. 4, pp. 161–165, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  140. G. Cocco, D. C. C. Chu, and S. Pandolfi, “Colchicine in clinical medicine. A guide for internists,” European Journal of Internal Medicine, vol. 21, no. 6, pp. 503–508, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  141. H. Abdul-Hussien, R. Hanemaaijer, J. H. Verheijen, J. H. van Bockel, R. H. Geelkerken, and J. H. N. Lindeman, “Doxycycline therapy for abdominal aneurysm: improved proteolytic balance through reduced neutrophil content,” Journal of Vascular Surgery, vol. 49, no. 3, pp. 741–749, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  142. K. Yasui, “Thalidomide as immunomodulatory drug: pharmacological actions and its indications,” Japanese Journal of Clinical Immunology, vol. 33, no. 5, pp. 229–233, 2010. View at Publisher · View at Google Scholar
  143. B. Ladizinski, E. J. Shannon, M. R. Sanchez, and W. R. Levis, “Thalidomide and analogues: potential for immunomodulation of inflammatory and neoplastic dermatologic disorders,” Journal of Drugs in Dermatology, vol. 9, no. 7, pp. 814–826, 2010. View at Google Scholar · View at Scopus
  144. L. Caspary, “Vasculitides of large vessels,” Vasa, vol. 40, no. 2, pp. 89–98, 2011. View at Publisher · View at Google Scholar · View at PubMed
  145. P. Caramaschi, G. Poli, A. Bonora et al., “A study on thrombophilic factors in Italian Behcet's patients,” Joint Bone Spine, vol. 77, no. 4, pp. 330–334, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  146. N. Ş. Yaşar, F. Salgür, D. Ü. Cansu, T. Kaşifoǧlu, and C. Korkmaz, “Combined thrombophilic factors increase the risk of recurrent thrombotic events in Behcet's disease,” Clinical Rheumatology, vol. 29, no. 12, pp. 1367–1372, 2010. View at Publisher · View at Google Scholar · View at PubMed
  147. A. B. Haghighi and A. Safari, “Proposing an algorithm for treatment of different manifestations of neuro-Behcet's disease,” Clinical Rheumatology, vol. 29, no. 6, pp. 683–686, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  148. T. El Houari, L. Oukerraj, L. Ghzaiel et al., “Management of Behçet disease with multiple complications,” Hellenic Journal of Cardiology, vol. 50, no. 5, pp. 420–422, 2009. View at Google Scholar
  149. S. Ozen, Y. Bilginer, N. Besbas, N. A. Ayaz, and A. Bakkaloglu, “Behçet disease: treatment of vascular involvement in children,” European journal of pediatrics, vol. 169, no. 4, pp. 427–430, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  150. M. Piga, F. Puchades, I. Mayo, and D. D'Cruz, “Successful thrombolytic therapy for recurrent right ventricular thrombosis in Behçet's disease,” Clinical and Experimental Rheumatology, vol. 28, no. 4, supplement 60, pp. S76–S78, 2010. View at Google Scholar
  151. F. El Louali, A. Tamdy, A. Soufiani et al., “Cardiac thrombosis as a manifestation of Behçet syndrome,” Texas Heart Institute Journal, vol. 37, no. 5, pp. 568–571, 2010. View at Google Scholar · View at Scopus
  152. Z. Khammar, R. Berrady, A. Boukhrissa et al., “Intracardiac thrombosis in Behçet disease: clinical presentation and outcome of three cases,” Journal des Maladies Vasculaires, vol. 36, no. 4, pp. 270–273, 2011. View at Publisher · View at Google Scholar · View at PubMed
  153. S. Volpinari, C. Monaldini, J. G. Capone et al., “Headache in Behçet's disease: case reports and literature review,” Reumatismo, vol. 61, no. 3, pp. 174–181, 2009. View at Google Scholar · View at Scopus
  154. A. Sayed, H. Elwan, F. Fouad et al., “Behcet extracranial carotid aneurysms: is there still a role for ligation?” European Journal of Vascular and Endovascular Surgery, vol. 39, no. 1, pp. 17–22, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  155. R. Attia, J. Reidy, D. D'Cruz, and L. Lang-Lazdunski, “Pulmonary artery ligation with lung preservation in Behcet disease: report of a case with prolonged survival,” Journal of Thoracic and Cardiovascular Surgery, vol. 139, no. 4, pp. e93–e95, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  156. W. H. Kim, D. Choi, J. S. Kim, Y. G. Ko, Y. Jang, and W. H. Shim, “Effectiveness and safety of endovascular aneurysm treatment in patients with vasculo-Behçet disease,” Journal of Endovascular Therapy, vol. 16, no. 5, pp. 631–636, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  157. S. S. Nitecki, A. Ofer, T. Karram, H. Schwartz, A. Engel, and A. Hoffman, “Abdominal aortic aneurysm in Behçet's disease: new treatment options for an old and challlenging problem,” Israel Medical Association Journal, vol. 6, no. 3, pp. 152–155, 2004. View at Google Scholar
  158. B.-L. Ho, R.-T. Lin, Y.-F. Chen, and H.-F. Lin, “Behcet's disease with involvement of major arteries: a case report,” Acta Neurologica Taiwanica, vol. 17, no. 4, pp. 253–257, 2008. View at Google Scholar
  159. G. Espinosa, I. Blanco, J. M. Antón, M. Sánchez, P. Macchiarini, and J. A. Barberà, “Chronic thromboembolic pulmonary hypertension in Behçet's disease: effectiveness of endarterectomy,” Clinical and Experimental Rheumatology, vol. 28, no. 4, supplement 60, pp. S79–S81, 2010. View at Google Scholar
  160. P. Porcu, O. Chavanon, B. Bertrand et al., “Giant aneurysm of the proximal segment of the left anterior descending artery in a patient with Behçet's disease—a combined approach,” Canadian Journal of Cardiology, vol. 24, no. 10, pp. e73–e74, 2008. View at Google Scholar · View at Scopus
  161. M. Alidoosti, M. Marzban, and P. Yazdanifard, “Endovascular repair of post-surgical pseudoaneurysm of suprarenal abdominal aorta in a patient with Behcet's disease,” International Angiology, vol. 27, no. 4, pp. 350–352, 2008. View at Google Scholar · View at Scopus
  162. S. W. Han, G. W. Kim, J. Lee, Y. J. Kim, and Y. M. Kang, “Successful treatment with stent angioplasty for Budd-Chiari syndrome in Behçet's disease,” Rheumatology International, vol. 25, no. 3, pp. 234–237, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  163. C. W. Liu, W. Ye, B. Liu, R. Zeng, W. Wu, and M. D. Dake, “Endovascular treatment of aortic pseudoaneurysm in Behçet disease,” Journal of Vascular Surgery, vol. 50, no. 5, pp. 1025–1030, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  164. S. Yilmaz and K. A. Cimen, “Pulmonary artery aneurysms in Behçet's disease,” Rheumatology International, vol. 30, no. 10, pp. 1401–1403, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  165. N. Pipitone, I. Olivieri, F. Cantini, G. Triolo, and C. Salvarani, “New approaches in the treatment of Adamantiades-Behçet's disease,” Current Opinion in Rheumatology, vol. 18, no. 1, pp. 3–9, 2006. View at Google Scholar · View at Scopus
  166. K. Baki, P. M. Villiger, D. Jenni, T. Meyer, and J. H. Beer, “Behçet's disease with life-threatening haemoptoe and pulmonary aneurysms: complete remission after infliximab treatment,” Annals of the Rheumatic Diseases, vol. 65, no. 11, pp. 1531–1532, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  167. E. A. O'Leary, I. Sabahi, J. J. Ricotta, B. Walitt, and C. M. Akbari, “Femoral profunda artery aneurysm as an unusual first presentation of Behcet disease,” Vascular and Endovascular Surgery, vol. 45, no. 1, pp. 98–102, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  168. C. Hidalgo-Tenorio, J. M. Sabio-Sánchez, P. J. P. Linares, L. M. Salmerón, E. Ros-Die, and J. Jiménez-Alonso, “Magic syndrome and true aortic aneurysm,” Clinical Rheumatology, vol. 27, no. 1, pp. 115–117, 2008. View at Publisher · View at Google Scholar · View at PubMed
  169. F. Atzeni and P. Sarzi-Puttini, “Autoantibody production in patients treated with anti-TNF-α,” Expert Review of Clinical Immunology, vol. 4, no. 2, pp. 275–280, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  170. I. Altorjay, Z. Veréb, Z. Serfozo et al., “Anti-TNF-α antibody (infliximab) therapy supports the recovery of enos and VEGFR2 protein expression in endothelial cells,” International Journal of Immunopathology and Pharmacology, vol. 24, no. 2, pp. 323–335, 2011. View at Google Scholar
  171. A. Syngle, K. Vohra, A. Sharma, and L. Kaur, “Endothelial dysfunction in ankylosing spondylitis improves after tumor necrosis factor-α blockade,” Clinical Rheumatology, vol. 29, no. 7, pp. 763–770, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  172. F. Davatchi, H. Shams, M. Rezaipoor et al., “Rituximab in intractable ocular lesions of Behcet's disease; randomized single-blind control study (pilot study),” International Journal of Rheumatic Diseases, vol. 13, no. 3, pp. 246–252, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  173. S. Sadreddini, H. Noshad, M. Molaeefard, and R. Noshad, “Treatment of retinal vasculitis in Behçt's disease with rituximab,” Modern Rheumatology, vol. 18, no. 3, pp. 306–308, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  174. U. Kaneko, T. Kishi, M. Kikuchi et al., “Two patients with childhood-onset Behcet's disease successfully treated by anti-tumor necrosis factor therapy,” Japanese Journal of Clinical Immunology, vol. 33, no. 3, pp. 157–161, 2010. View at Publisher · View at Google Scholar
  175. M. F. Zhang, C. Zhao, X. Wen, H. Du, and Y. Zhao, “The short-term efficacy and safety treatment study of recurrent uveitis in Behcet disease with etanercept,” Chinese Journal of Ophthalmology, vol. 46, no. 2, pp. 145–150, 2010. View at Publisher · View at Google Scholar · View at Scopus
  176. Z. Szekanecz, G. Kerekes, and P. Soltész, “Vascular effects of biologic agents in RA and spondyloarthropathies,” Nature Reviews Rheumatology, vol. 5, no. 12, pp. 677–684, 2009. View at Publisher · View at Google Scholar · View at PubMed
  177. I. Kötter, V. Hamuryudan, Z. E. A-Ztürk, and H. Yazici, “Interferon therapy in rheumatic diseases: state-of-the-art 2010,” Current Opinion in Rheumatology, vol. 22, no. 3, pp. 278–283, 2010. View at Publisher · View at Google Scholar · View at PubMed
  178. K. Namba, K. H. Sonoda, H. Kitamei et al., “Granulocytapheresis in patients with refractory ocular Behcet's disease,” Journal of clinical apheresis, vol. 21, no. 2, pp. 121–128, 2006. View at Google Scholar · View at Scopus
  179. T. Daikeler, I. Kötter, C. B. Tyndall et al., “Haematopoietic stem cell transplantation for vasculitis including Behçet's disease and polychondritis: a retrospective analysis of patients recorded in the European Bone Marrow Transplantation and European League Against Rheumatism databases and a review of the literature,” Annals of the Rheumatic Diseases, vol. 66, no. 2, pp. 202–207, 2007. View at Publisher · View at Google Scholar · View at PubMed
  180. M. T. Inanc, N. Kalay, T. Heyit et al., “Effects of atorvastatin and lisinopril on endothelial dysfunction in patients with Behçet's disease,” Echocardiography, vol. 27, no. 8, pp. 997–1003, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus