In Vitro and In Vivo Evaluation of pH-Sensitive Hydrogels of Carboxymethyl Chitosan for Intestinal Delivery of Theophylline

Table 3

Model fitting for different formulations.

	𝑅^2
	F1	F2	F3	F4	F5
Zero order	0.763	0.682	0.714	0.701	0.670
First order	0.861	0.737	0.752	0.737	0.00
Higuchi	0.902	0.829	0.901	0.890	0.832
Peppas	0.957	0.910	0.950	0.963	0.897
Best fit model	Peppas	Peppas	Peppas	Peppas	Peppas
Diffusion exponent Peppas model	𝑛=0.6937	𝑛=0.5826	𝑛=0.784	𝑛=0.752	𝑛=0.652