Research Article
In Vitro and In Vivo Evaluation of pH-Sensitive Hydrogels of Carboxymethyl Chitosan for Intestinal Delivery of Theophylline
Table 4
A statistical comparison of the mean values of pharmacokinetic parameters of product A and B.
| | Parameters | Product A | Product B | |
| | 12.34 ± 2.42 μg/mL | 09.69 ± 4.12 μg/mL | <0.05 | | 5.0 ± 0.81 hr | 6.0 ± 0.75 hr | <0.05 | | Kel | 0.08410 h−1 | 0.07813 h−1 | <0.05 | | t
1/2 | 8.24 ± 4.7 hrs | 8.87 ± 5.74 hrs | <0.05 | | 101.73 ± 16.5 μg·hr/mL | 123.17 ± 21.5 μg·hr/mL | <0.05 |
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