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ISRN Pediatrics
Volume 2012 (2012), Article ID 763783, 7 pages
Research Article

Screening for Celiac Disease in Children with Dental Enamel Defects

1Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt
2Department of Clinical and Chemical Pathology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt
3Department of Orthodontic and Pediatric, Faculty of Dentistry, Ain Shams University, Cairo 11566, Egypt
4Ministry of Health, Cairo, Egypt

Received 21 March 2012; Accepted 17 April 2012

Academic Editors: M. S. Anderson and H. Neville

Copyright © 2012 Mostafa Abdel-Aziz El-Hodhod et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Dental enamel defects (DEDs) are seen in celiac disease (CD). Aim was to detect frequency of CD among such patients. Methods. This study included 140 children with DED. They were tested for CD. Gluten-free diet (GFD) was instituted for CD patients. A cohort of 720, age and sex-matched, normal children represented a control group. Both groups were evaluated clinically. Serum calcium, phosphorus, alkaline phosphatase, serum IgA, and tissue transglutaminase (tTG) IgG and IgA types were measured. Results. CD was more diagnosed in patients with DEDs (17.86%) compared to controls (0.97%) ( ๐‘ƒ < 0 . 0 0 0 1 ). Majority of nonceliac patients showed grade 1 DED compared to grades 1, 2, and 3 DED in CD. Five children had DED of deciduous teeth and remaining in permanent ones. After 1 year on GFD, DED improved better in CD compared to nonceliac patients. Gastrointestinal symptoms did not vary between celiac and nonceliac DED patients. Lower serum calcium significantly predicted CD in this cohort. Conclusion. CD is more prevalent among children with DED than in the general population. These DEDs might be the only manifestation of CD; therefore, screening for CD is highly recommended among those patients especially in presence of underweight and hypocalcemia.