High Dose Infliximab in the Treatment of Refractory Uveitis: Does Dose Matter?

Table 1

Demographic and treatment characteristics of children treated with high dose (HD), moderate dose (MD), and low dose (LD) Infliximab.

	No.	Age (yr)	Gender	Ethnicity	Ocular diagnosis	Systemic diagnosis	Age at diagnosis (yr)	Age at starting treatment (yr)	Failed meds before INF	Duration of treatment with Steroids before INF (mo)
HD	1	20	F	H	Anterior	ERA	15	20	MTX, PRED, TPRED	56
	2	7	F	H	Anterior	Poly JIA	5	7	MTX, PRED, TPRED	22
	3	9	F	H	Anterior	Idiopathic	7	9	MTX, TPRED, PRED, MMF	20
	4	11	F	H	Anterior	CNO	9	11	MTX, TPRED, PRED	22
	5	16	M	C	Intermediate	Idiopathic	8	16	MTX, PRED, TPRED	80
	6	18	F	H	Posterior	Idiopathic	13	18	MTX, TPRED	56
	7	6	F	H	Panuveitis	Idiopathic	5	6	MTX, TPRED	10
	8	7	M	C	Panuveitis	VKH	5.5	7	MTX, TPRED	12
	9	15	F	H	Panuveitis	VKH	10	15	MTX, PRED, TPRED	56
MD	10	4	M	C	Anterior	PSA	3	4	MTX/TPRED	10
	11	13	M	C	Anterior	ERA	11.5	13	MTX/TPRED	12
	12	13	F	C	Anterior	Oligo JIA	8	11	MTX, TPRED	36
	13	2	F	H	Anterior	Oligo JIA	1	2	MTX, TPRED	10
	14	6	M	C	Anterior	Oligo JIA	3.8	6	MTX, TPRED, PRED	20
	15	9	M	C	Anterior	Idiopathic	6	9	MTX,TPRED	28
	16	5	M	C	Intermediate	Idiopathic	3	5	MTX, TPRED	20
	17	5	M	C	Posterior	Idiopathic	3.5	5	MTX, TPRED	16
	18	11	F	H	Posterior	Idiopathic	8	11	MTX, TPRED, PRED, AZA	20
	19	8	F	H	Posterior	Idiopathic	6.5	8	MTX, TPRED, PRED	12
	20	18	F	H	Posterior	Sarcoidosis	13	18	MTX,TPRED	50
MD	21	13	M	C	Panuveitis	Idiopathic	9	13	MTX, TPRED, PRED	46
	22	15	F	H	Panuveitis	Idiopathic	13	15	MTX, TPRED	20
	23	14	M	C	Panuveitis	Idiopathic	12	14	MTX, TPRED, PRED	22
	24	15	M	C	Panuveitis	Idiopathic	13	15	MTX, TPRED	20
	25	16	F	H	Panuveitis	Idiopathic	13	16	MTX, TPRED	28
	26	11	M	C	Panuveitis	Idiopathic	8	11	MTX	28
	27	16	F	H	Panuveitis	Idiopathic	14	16	MTX/TPRED	22
	28	14	M	C	Panuveitis	Blau syndrome	9	14	MTX, TPRED, PRED	48
LD	29	12	F	H	Anterior	Poly JIA	10.5	12	MTX, PRED, TPRED	8
	30	8	F	H	Anterior	ERA	6	8	MTX/CYS/TPRED	22
	31	10	F	C	Anterior	Poly JIA	8.5	10	MTX/TPRED	8
	32	12	M	A	Anterior	Oligo JIA	10.5	12	MTX/TPRED	6
	33	11	M	C	Anterior	Oligo JIA	9.5	11	MTX/TPRED	8
	34	12	F	C	Anterior	Oligo JIA	8.5	12	MTX/TPRED	12

HD-high dose; MD-moderate dose; LD-low dose; M-male; F-female; H-hispanic; C-caucasian; A-african american; ERA-enthesitis-related arthritis; Poly JIA-polyarticular juvenile idiopathic arthritis; oligo JIA-oligoarticular juvenile idiopathic arthritis; MTX-methotrexate; PRED-prednisone; AZA-azathioprine; TPRED-topical prednisone; CYS-cyclosporine; MMF-mycophenolate mofetil; PSA-psoriatic arthritis; VKH-vogt-koyanagi-harada syndrome; CNO-chronic noninfectious osteomyelitis; Yr-year; Mo-month.