Table of Contents
ISRN Hematology
Volume 2012, Article ID 768718, 6 pages
http://dx.doi.org/10.5402/2012/768718
Clinical Study

Clinical and Electrocardiographic Evaluation of Sickle-Cell Anaemia Patients with Pulmonary Hypertension

1Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria
2Department of Medicine, Federal Medical Centre Asaba, Delta State, Nigeria
3Department of Haematology, University of Nigeria Teaching Hospital, Enugu, Nigeria

Received 15 November 2011; Accepted 17 January 2012

Academic Editors: Y. Furukawa and H. Gisslinger

Copyright © 2012 N. I. Oguanobi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pulmonary hypertension is an emerging complication of sickle cell anaemia with associated increased risk of mortality. In order to evaluate the clinical and electrocardiographic findings in adult sickle-cell patients with pulmonary hypertension, a cross sectional study was conducted on sixty two sickle cell anaemia patients and sixty two age and sex matched normal controls. Elevated pulmonary artery pressures (PAP), defined by PAP ≥ 30 mm Hg on echocardiography, was demonstrated in 41.9% of patients with sickle cell anaemia and in 3.2% of the controls; πœ’ 2 = 2 6 . 5 7 1 , 𝑃 < 0 . 0 0 1 . Right ventricular hypertrophy, increased P-wave duration, QTc interval, and QTc dispersion were significantly associated with pulmonary hypertension. Significant correlation was found between mean PAP and (1) Frequency of crisis (Spearman correlation = 0.320; 𝑃 = 0 . 0 1 1 ), (2) body mass index (Pearson’s correlation = −0.297; 𝑃 = 0 . 0 1 9 ), and (3) QTc interval (Pearson’s correlation 0.261; 𝑃 = 0 . 0 4 0 ). Pulmonary hypertension in adult sickle anaemia patients is associated with electrocardiographic evidence of right ventricular hypertrophy, and correlates significantly with frequency of vaso-occlusive crisis, and QTc interval. The observations by this study tend to suggest that these parameters could be useful for early detection and prevention of pulmonary hypertension in patients with sickle cell anaemia.