Adiponectin Fails in Improving Angiogenic Repair in Streptozocin-Treated or Lepr^db/db Mice after Hind Limb Ischemia

Figure 2

Reduced capillary density in ischemic hind limbs of db1 and Lepr^db/db mice. (a) Representative immunostaining of ischemic tissues from WT, db1, and Lepr^db/db mice with anti-CD31 monoclonal antibody (brown) on postoperative day 14. (b) Quantitative analysis of capillary density in ischemic (=I) and contralateral (=C) adductor muscle of WT, db1, and Lepr^db/db mice on postoperative day 14 (𝑛=6 in each group). Capillary density was expressed as the number of capillaries per high power field (×400, (a)) and capillaries per muscle fiber (b). *𝑃<0.01.

(a)

(b)