Table of Contents
ISRN Pharmacology
Volume 2012, Article ID 782656, 10 pages
http://dx.doi.org/10.5402/2012/782656
Research Article

Doripenem Dosing Recommendations for Critically Ill Patients Receiving Continuous Renal Replacement Therapy

1Clinical Pharmacology, Janssen Research & Development, L.L.C., 920 Route 202, Raritan, NJ 08869, USA
2Clinical Research and Public Policy, School of Pharmacy, Virginia Commonwealth University, MCV Campus, 215 McGuire Hall, 1112 East Clay Street, P.O. Box 980533, Richmond, VA 23298, USA
3Clinical Development, Janssen Research & Development, L.L.C, 6500 Paseo Padre Parkway, B-1, Fremont, CA 94555, USA
4Clinical Pharmacology, Janssen Research & Development, L.L.C., 1125 Trenton-Harbourton Road, Titusville, NJ 08650, USA

Received 17 April 2012; Accepted 30 May 2012

Academic Editors: M. Brunner, K. Cimanga, and H. Kankaanranta

Copyright © 2012 Mahesh N. Samtani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. N. Jones, H. K. Huynh, D. J. Biedenbach, T. R. Fritsche, and H. S. Sader, “Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations,” Journal of Antimicrobial Chemotherapy, vol. 54, no. 1, pp. 144–154, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. C. M. Pillar, M. K. Torres, N. P. Brown, D. Shah, and D. F. Sahm, “In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States,” Antimicrobial Agents and Chemotherapy, vol. 52, no. 12, pp. 4388–4399, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. Ortho-McNeil-Janssen Pharmaceuticals, Inc., “Doribax Prescribing Information 2007,” 2010, http://doribax.com/shared/pi/doribax.pdf.
  4. European Medicines Authority, “Summary of product characteristics: Doribax,” 2011, http://www.emea.europa.eu/humandocs/Humans/EPAR/doribax/doribax.htm.
  5. I. Cirillo, N. Vaccaro, K. Turner, B. Solanki, J. Natarajan, and R. Redman, “Pharmacokinetics, safety, and tolerability of doripenem after 0.5-, 1-, and 4-hour infusions in healthy volunteers,” Journal of Clinical Pharmacology, vol. 49, no. 7, pp. 798–806, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Nandy, M. N. Samtani, and R. Lin, “Population pharmacokinetics of doripenem based on data from phase 1 studies with healthy volunteers and phase 2 and 3 studies with critically ill patients,” Antimicrobial Agents and Chemotherapy, vol. 54, no. 6, pp. 2354–2359, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. I. Cirillo, N. Vaccaro, B. Castaneda-Ruiz, K. Turner, and R. Redman, “Pharmacokinetics of doripenem in subjects with varying degrees of renal impairment (abstract A-1886),” in Proceedings of the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy and the 46th Annual Meeting of the Infectious Diseases Society of America, Washington, DC, USA, October 2008.
  8. J. Cerdá and C. Ronco, “Modalities of continuous renal replacement therapy: technical and clinical considerations,” Seminars in Dialysis, vol. 22, no. 2, pp. 114–122, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. M. S. Joy, G. R. Matzke, D. K. Armstrong, M. A. Marx, and B. J. Zarowitz, “A primer on continuous renal replacement therapy for critically ill patients,” Annals of Pharmacotherapy, vol. 32, no. 3, pp. 362–375, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. P. M. Palevsky, “Dialysis modality and dosing strategy in acute renal failure,” Seminars in Dialysis, vol. 19, no. 2, pp. 165–170, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. B. H. Heintz, G. R. Matzke, and W. E. Dager, “Antimicrobial dosing concepts and recommendations for critically Ill adult patients receiving continuous renal replacement therapy or intermittent hemodialysis,” Pharmacotherapy, vol. 29, no. 5, pp. 562–577, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Kuang, A. Verbine, and C. Ronco, “Pharmacokinetics and antimicrobial dosing adjustment in critically ill patient during continous renal replacement theraphy,” Clinical Nephrology, vol. 67, no. 5, pp. 267–284, 2007. View at Google Scholar · View at Scopus
  13. F. Pea, P. Viale, F. Pavan, and M. Furlanut, “Pharmacokinetic considerations for antimicrobial therapy in patients receiving renal replacement therapy,” Clinical Pharmacokinetics, vol. 46, no. 12, pp. 997–1038, 2007. View at Google Scholar · View at Scopus
  14. I. Cirillo, N. Vaccaro, D. Balis, R. Redman, and G. R. Matzke, “Influence of continuous venovenous hemofiltration and continuous venovenous hemodiafiltration on the disposition of doripenem,” Antimicrobial Agents and Chemotherapy, vol. 55, no. 3, pp. 1187–1193, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. A. M. Vilay, M. D. Churchwell, and B. A. Mueller, “Clinical review: drug metabolism and nonrenal clearance in acute kidney injury,” Critical Care, vol. 12, no. 6, p. 235, 2008. View at Google Scholar · View at Scopus
  16. W. A. Craig, “Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men,” Clinical Infectious Diseases, vol. 26, no. 1, pp. 1–12, 1998. View at Google Scholar · View at Scopus
  17. G. L. Drusano, “Antimicrobial pharmacodynamics: critical interactions of “bug and drug”,” Nature Reviews Microbiology, vol. 2, no. 4, pp. 289–300, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. J. D. Turnidge, “The pharmacodynamics of β-lactams,” Clinical Infectious Diseases, vol. 27, no. 1, pp. 10–22, 1998. View at Google Scholar · View at Scopus
  19. M. N. Samtani, R. Flamm, K. Kaniga, and P. Nandy, “Pharmacokinetic-pharmacodynamic-model-guided doripenem dosing in critically ill patients,” Antimicrobial Agents and Chemotherapy, vol. 54, no. 6, pp. 2360–2364, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. Clinical and Laboratory Standards Institute, “Performance Standards for Antimicrobial Susceptibility Testing, Supplement to M-100, June 2010 Update,” AST Meeting Minutes, January 2010.
  21. J. R. Prowle and R. Bellomo, “Continuous renal replacement therapy: recent advances and future research,” Nature Reviews Nephrology, vol. 6, no. 9, pp. 521–529, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. O. Burkhardt, C. Hafer, A. Langhoff et al., “Pharmacokinetics of ertapenem in critically ill patients with acute renal failure undergoing extended daily dialysis,” Nephrology Dialysis Transplantation, vol. 24, no. 1, pp. 267–271, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. D. N. Fish, I. Teitelbaum, and E. Abraham, “Pharmacokinetics and pharmacodynamics of imipenem during continuous renal replacement therapy in critically ill patients,” Antimicrobial Agents and Chemotherapy, vol. 49, no. 6, pp. 2421–2428, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Langgartner, A. Vasold, T. Glück, M. Reng, and F. Kees, “Pharmacokinetics of meropenem during intermittent and continuous intravenous application in patients treated by continuous renal replacement therapy,” Intensive Care Medicine, vol. 34, no. 6, pp. 1091–1096, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. European Medicines Agency, “European Public Assessment Report (EPAR)—Doribax,” 2012, http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000891/human_med_000744.jsp&murl=menus/medicines/medicines.jsp&mid=WC0b01ac058001d124#.