International Scholarly Research Notices

Review Article

Nuclear Magnetic Resonance Spectroscopy in the Detection and Characterisation of Cardiovascular Disease: Key Studies

Table 2

Summary of lipoprotein changes from lipoprotein profiling studies.


Study	Size	VLDL	LDL	HDL	Author

Children with FH versus non FH siblings	144 versus 45	T↑ S Sz↓	T↑ I↑ L↑ S↑	T↓ L↓ M↓	van der Graaf et al. [31]

Drug treatment of children with FH: pravastatin versus placebo for 1 year	68 versus 76	T↓ M↓ S↓ Sz↑	T↓ L↓	T↑ L↑ M↑	van der Graaf et al. [31]

Effect of AT on stable CAD with statins: AT versus placebo	42 versus 43	no change	no change	no change	Singh et al. [33]

HIV-infection: study start samples, nonfatal CVD event versus non-CVD event during study	124 versus 240			T↓ L↓ S↓	Duprez et al. [35]

HIV-infection: last sample prior to CVD event versus non-CVD event (HDL only)	195 versus 368			T↓ S↓	Duprez et al. [35]

HIV treatment: DC versus VS (HDL only)	249 versus 248			T↓ M↓ S↓	Duprez et al. [35]

Male versus female	1574 versus 1692	T↑ L↑ I↑ Sz↑	T↑ L↓ I↑ S↑ Sz↓	L↓ I↑ S↑ Sz↓	Freedmanet al. [36]

IMT severity	5388	T↑ L↑ S↑	T↑ S↑ I↑ S↓	T↓ L↓ Sz↓	Mora et al. [32]

IMT severity in Alaskan Eskimos	656		T↑		Masulli et al. [37]

Carotid plaque severity in Alaskan Eskimos	656	L↓ S↓	L↑		Masulli et al. [37]

Met Syn versus control	641 versus 2352	T↑ L↑ I↑ Sz↑	T↑ I↑ L↓ S↑ Sz↓	T↓ L↓ I↓, S (Ma↓, F↑) Sz↓	Kathiresan et al. [39]

Met Syn, number of Met Syn components (LDL only)	2993		T↑ L↓ S↑		Kathiresan et al. [39]

Developed diabetes by study end versus nondiabetic at study end	130 versus 700	T↑ L↑ Sz↑	T↑ S↑ Sz↓	L↓ S↑ Sz↓	Festa et al. [41]

Diabetic at study start versus developed diabetes by study end	513 versus 130	L↑ Sz↑	L↓ Sz↓	S↓	Festa et al. [41]

Non-CVD women: developed CVD within 11 years versus not developed CVD	1015 versus 26658	T↑ L↑ M↑ S↑ Sz↑	T↑ I↑ S↑ Sz↓	L↓ Sz↓	Mora et al. [42]

↑/↓: increased/decreased level of lipoproteins with increasing severity of condition in study or first group of patients per study versus second; AT: -tocopherol; CAD: coronary artery disease; CVD: cardiovascular disease; DC: intermittent antiretroviral therapy; F: female; FH: familial hypercholesterolemia; HDL: high density lipoprotein; HIV: human immunodeficiency virus; I: intermediate density lipoprotein; IMT: intima-media thickness; L: large; LDL: low density lipoprotein; M: medium; Ma: male; Met Syn: metabolic syndrome; S: small; Sz: size; T: total; VLDL: very low density lipoprotein; VS: continuous antiretroviral therapy.