Variable Resistance of RMS to Interferon γ Signaling
Figure 1
RMS cells are highly resistance against IFNγ induced cell death. (a) Survival of RMS cell lines and HT29 control cells after IFNγ treatment; cells were incubated for different periods of time with 100 ng/mL IFNγ in starvation media with 1% FCS; survival of nontreated tumour cells (0 h) was set 100%. Continuous line reflects cells without IFNγ treatment; dashed line correspondent to IFNγ treated cells; (b) summarizes effects after 96 h of treatment with (dark grey bars) and without (light grey bars) IFNγ. Data represent the mean of triplicates + SEM; one representative experiment out of 3 is shown. Statistical analysis was performed using Student's t-test. *P < 0.05; **P < 0.01; ***P < 0.001.
