Table of Contents
ISRN Neurology
Volume 2012, Article ID 792192, 6 pages
Research Article

Predictors of Conversion to Multiple Sclerosis in Patients with Clinical Isolated Syndrome Using the 2010 Revised McDonald Criteria

1Division of Neurology, Amiri Hospital, Qurtoba 73767, Kuwait
2Division of Neurology, Dasman Diabetes Institute, P.O. Box 1180, Dasman 15462, Kuwait
3Department of Neurology, Ibn Sina Hospital, P.O. Box 25427, Safat 13115, Kuwait
4Department of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait
5Department of Neurology and Psychiatry, Minia University, P.O. Box 61519, Minia 61111, Egypt

Received 30 July 2012; Accepted 8 October 2012

Academic Editors: A. K. Erdemoglu and D. Mathieu

Copyright © 2012 R. Alroughani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Clinically isolated syndrome (CIS) is the first neurologic episode of multiple sclerosis (MS). Magnetic resonance imaging (MRI) and clinical features are used to predict risk of conversion to MS. Objectives. The aim of this prospective study is to evaluate predictors of conversion of CIS to McDonald MS. Method. 97 patients with CIS have been followed for 2 years. Age of onset, gender, initial clinical presentation, and MRI brain and spine were assessed. The 2010 revised McDonald criteria were applied. Results. Fifty-nine patients (60.8%) with CIS converted to McDonald MS after 10.1 4.2 months. Thirty-seven (38.1%) of the convertors satisfied the diagnostic criteria based on the radiological parameters, while 21.7% sustained their second clinical events. A multivariate regression analysis revealed that high number of lesions in MRI ( ) and earlier age of onset ( ) predicted the conversion of CIS to McDonald MS. Gender ( ) and initial clinical presentation (optic pathway ( ), supratentorial ( ), brain stem/ cerebellum ( ), and spinal ( )) were not statistically significant. Conclusion. Age of onset and MRI parameters can be used as predictors of CIS conversion to McDonald MS. Application of the 2010 revised McDonald criteria allows an earlier MS diagnosis.