Table of Contents
ISRN Veterinary Science
Volume 2012, Article ID 794148, 8 pages
http://dx.doi.org/10.5402/2012/794148
Research Article

Evaluation of Oral Robenacoxib for the Treatment of Postoperative Pain and Inflammation in Cats: Results of a Randomized Clinical Trial

1New Product Development, Novartis Animal Health Inc., Greensboro, NC 27408, USA
2Clinical Development, Novartis Animal Inc., 4058 Basel, Switzerland

Received 29 March 2012; Accepted 8 May 2012

Academic Editors: I. Nsahlai and F. Titti

Copyright © 2012 Stephen King et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The efficacy and safety of robenacoxib were assessed for the control of postoperative pain and inflammation in cats. The study was a multicenter, prospective, randomized, blinded, and parallel group clinical trial. A total of 249 client-owned cats scheduled for forelimb onychectomy plus either ovariohysterectomy or castration surgeries were included. All cats received butorphanol prior to anesthesia and forelimb four-point regional nerve blocks with bupivacaine after induction of general anesthesia. Cats were randomized to receive daily oral tablet robenacoxib, at a mean (range) dosage of 1.84 (1.03–2.40) mg/kg ( 𝑛 = 1 6 7 ) , or placebo ( 𝑛 = 8 2 ) , once prior to surgery and for two days postoperatively. Significantly ( 𝑃 < 0 . 0 5 ) fewer robenacoxib cats received additional analgesia rescue therapy (16.5%) than placebo cats (46.3%). Pain elicited on palpation of the soft tissue incision site, behavior following social interaction, and posture assessed during the first 8 hours after extubation were significantly ( 𝑃 < 0 . 0 5 ) improved in cats receiving robenacoxib. Frequency of reported adverse clinical signs, hematology, serum chemistry and urinalysis variables, and body weight changes weresimilar between groups. In conclusion, robenacoxib was effective and well tolerated in the control of postoperative pain and inflammation in cats undergoing onychectomy with ovariohysterectomy or castration.