A New Strategy to Find Targets for Anticancer Therapy: Chemokine CXCL14/BRAK Is a Multifunctional Tumor Suppressor for Head and Neck Squamous Cell Carcinoma
Figure 2
CXCL14/BRAK expression in oral carcinoma cells (HSC-3) completely suppresses growth of tumor cell xenografts in SCID mice. (A) Photographs of tumor cell xenografts after 27 days. BRAK-expressing cell clones or mock vector-transfected cells (5 106) were inoculated subcutaneously into both sides of the back region of 10 female SCID mice, representative animals were photographed 27 days after xenografting. (a), (b) BRAK-expressing cells. (c), (d) Mock vector-transfected cells. (B) Effect of BRAK expression on HSC-3 tumor xenografts in SCID mice. Pooled clones of BRAK-expressing (BRAK) and mock vector-transfected (Mock) cells (5 106/site) were inoculated subcutaneously into both sides of the back region of 10 female SCID mice. Mock: open circles, average of 20 tumors in 10 animals. BRAK: closed circles, average of 20 tumors in 10 animals. A significant difference in the size of tumors was observed at all points measured. (Student’s t-test). (Cited from [2]).
