Synthesis of New Fused Benzothiadiazepines and Macrocyclic Sulfamides Starting from N,N-Disubstituted Sulfamides and N(Boc)-Sulfamides
Scheme 2
General synthesis of tricyclic benzothiadiazepine-1,1-dioxides. Reagents and conditions: (f) α,α′-dibromo-xylene, K2CO3, CH3CN, reflux, 4 h (g) K2CO3, 2,3,4,5-tetrakis(bromomethyl)benzene, CH3CN, reflux 10 h.