Research Article
In Vitro-In Vivo Correlation Evaluation of Generic Alfuzosin Modified Release Tablets
Table 6
In vitro-in vitro correlation table at different dissolution media to select discriminative dissolution media for in vitro drug release.
| | Dissolution medium pH | PK parameters | Predicted | Observed | % PE | Ratio |
| | 1.2 | AUClast (ng/mL * h) |
61.70
|
63.35
| −2.62 |
0.97
| | (ng/mL) |
1.33
|
1.09
|
22.02
|
1.22
|
| | 4.7 | AUClast (ng/mL * h) |
61.85
|
63.35
| −2.38 |
0.98
| | (ng/mL) |
1.29
|
1.09
|
18.74
|
1.19
|
| | 6.8 | AUClast (ng/mL * h) |
61.88
|
63.35
| −2.32 |
0.98
| | (ng/mL) |
1.28
|
1.09
|
17.68
|
1.18
|
|
|
