Conservation, Compensation, and Evolution of N-Linked Glycans in the HIV-1 Group M Subtypes and Circulating Recombinant Forms

Table 1

gp120 variable loop glycosylation. The average, median, range of lengths (number of amino acids), and number of predicted N-linked glycosylated positions for the gp120 variable loops of each of the HIV-1 group M subtypes and CRFs studied.

	A			B			C			D			AE			AG
	AV	MED	RA	AV	MED	RA	AV	MED	RA	AV	MED	RA	AV	MED	RA	AV	MED	RA
	Length
V1/V2	68	68	57–92	68	68	46–85	68	67	51–89	65	67	57–82	69	69	55–85	66	65	53–89
V3	34	34	25–35	34	34	31–38	34	34	24–36	33	33	33–35	34	34	34–35	34	34	33–34
V4	31	30	22–40	31	31	15–41	27	27	17–39	30	30	21–37	27	27	18–39	31	31	24–38
V5	10	10	9–13	11	11	9–19	11	11	7–19	11	10.5	8–16	10	10	8–13	10	10	9–15
	Number of glycosylated positions
V1/V2	6	6	3–10	6	6	3–9	6	6	1–10	6	6	3–8	6	6	3–11	6	6	3–10
V3	1	1	NA	1	1	1-2	1	1	1-2	1	1	NA	1	1	1-2	1	1	1-2
V4	5	5	2–7	5	5	2–7	4	4	1–7	5	5	2–7	4	4	2–6	5	5	3–7
V5	2	2	1–3	1	1	1–3	1	1	1–4	2	2	1–3	2	2	1–3	2	2	1–3

AV: average, MED: median, RA: range.