Table of Contents
ISRN Oncology
Volume 2012, Article ID 828701, 8 pages
http://dx.doi.org/10.5402/2012/828701
Review Article

In Silico Experimental Modeling of Cancer Treatment

1Mathematical Sciences Discipline, Queensland University of Technology, P.O. Box 2434, Brisbane, QLD 4001, Australia
2Institute of Health and Biomedical Innovation, Queensland University of Technology, P.O. Box 2434, Brisbane, QLD 4001, Australia

Received 21 September 2011; Accepted 28 October 2011

Academic Editors: A. M. Garcia-Lora, F. Kuhnel, and M. Stracke

Copyright © 2012 Trisilowati and D. G. Mallet. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In silico experimental modeling of cancer involves combining findings from biological literature with computer-based models of biological systems in order to conduct investigations of hypotheses entirely in the computer laboratory. In this paper, we discuss the use of in silico modeling as a precursor to traditional clinical and laboratory research, allowing researchers to refine their experimental programs with an aim to reducing costs and increasing research efficiency. We explain the methodology of in silico experimental trials before providing an example of in silico modeling from the biomathematical literature with a view to promoting more widespread use and understanding of this research strategy.