Table of Contents
ISRN Hematology
Volume 2012, Article ID 839242, 7 pages
Clinical Study

The Platelet Function Analyzer (PFA-100) as a Screening Tool in Neurosurgery

1Medizinische Fakultät, Philipps-Universität Marburg, Conradistraße, 35043 Marburg, Germany
2Praxis für Transfusionsmedizin, Aachener Straße 313, 50931 Köln, Germany
3Klinik für Neurochirurgie, Philipps-Universität Marburg, Conradistraße, 35043 Marburg, Germany
4Klinik für Neurochirurgie, Universitätsklinikum Essen, Hufelandstraße 55, 45147 Essen, Germany

Received 18 April 2012; Accepted 18 June 2012

Academic Editors: A. Bosly, K. L. Dikshit, I. C. Haznedaroglu, and J. Yu

Copyright © 2012 Ralf Karger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We investigated whether the inclusion of the PFA-100 in the preoperative screening of neurosurgical patients might reduce perioperative bleeding complications. Patients with intracranial space-occupying lesions who were scheduled for neurosurgery underwent routine preoperative PFA-100 testing. In case of an abnormal PFA test, patients received prophylactic treatment with desmopressin. 93 consecutive patients were compared to 102 consecutive patients with comparable characteristics operated before introduction of the PFA-100 testing. 2 patients (2.2%) in the PFA group and 2 patients (2.0%) in the non-PFA group experienced clinically relevant intracranial bleeding confirmed by computed tomography (OR 1.05, 95% CI 0.39–2.82; 𝑃 = 1 . 0 ). Transfusions were not significantly different between the two groups. 13 (14.0%) patients in the PFA group and 5 (4.9%) patients in the non-PFA group received desmopressin (OR 3.2, 95% CI 1.1–9.2; 𝑃 = 0 . 0 4 5 ). Preoperative screening with the PFA-100 did result in a significant increase in the administration of desmopressin, which could not reduce perioperative bleeding complications or transfusions.