Table of Contents
ISRN Pulmonology
Volume 2012 (2012), Article ID 840489, 7 pages
http://dx.doi.org/10.5402/2012/840489
Research Article

Matrix Metalloproteinases-9 (MMPs-9) and -12 Are Upregulated in the Airways of Mice with Chronic Airway Inflammation and Remodeling

1Department of Pharmacology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan
2Department of Biology, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Received 3 September 2011; Accepted 8 October 2011

Academic Editors: P. Bartsch and M. Tatar

Copyright © 2012 Yingyan Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. M. Warner and D. A. Knight, “Airway modeling and remodeling in the pathogenesis of asthma,” Current Opinion in Allergy and Clinical Immunology, vol. 8, no. 1, pp. 44–48, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. D. Broide, “New perspectives on mechanisms underlying chronic allergic inflammation and asthma in 2007,” Journal of Allergy and Clinical Immunology, vol. 122, no. 3, pp. 475–480, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. P. K. Jeffery, A. Laitinen, and P. Venge, “Biopsy markers of airway inflammation and remodelling,” Respiratory Medicine, vol. 94, pp. S9–S15, 2000. View at Google Scholar · View at Scopus
  4. H. Nagaset and J. F. Woessner, “Matrix metalloproteinases,” Journal of Biological Chemistry, vol. 274, no. 31, pp. 21491–21494, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. K. J. Greenlee, Z. Werb, and F. Kheradmand, “Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted,” Physiological Reviews, vol. 87, no. 1, pp. 69–98, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. V. Lagente, B. Manoury, S. Nénan, C. Le Quément, C. Martin-Chouly, and E. Boichot, “Role of matrix metalloproteinases in the development of airway inflammation and remodeling,” Brazilian Journal of Medical and Biological Research, vol. 38, no. 10, pp. 1521–1530, 2005. View at Google Scholar · View at Scopus
  7. F. W. S. Ko, C. Diba, M. Roth et al., “A comparison of airway and serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with asthmatic mucus hypersecretion,” Chest, vol. 127, no. 6, pp. 1919–1927, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. S. Xie, R. Issa, M. B. Sukkar et al., “Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells,” Respiratory Research, vol. 6, article 148, 2005. View at Publisher · View at Google Scholar · View at PubMed
  9. H. Ohbayashi and K. Shimokata, “Matrix metalloproteinase-9 and airway remodeling in asthma,” Current Drug Targets, vol. 4, no. 2, pp. 177–181, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. V. Lagente, C. Le Quement, and E. Boichot, “Macrophage metalloelastase (MMP-12) as a target for inflammatory respiratory diseases,” Expert Opinion on Therapeutic Targets, vol. 13, no. 3, pp. 287–295, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. D. D. Cataldo, K. G. Tournoy, K. Vermaelen et al., “Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation,” American Journal of Pathology, vol. 161, no. 2, pp. 491–498, 2002. View at Google Scholar · View at Scopus
  12. S. J. McMillan, J. Kearley, J. D. Campbell et al., “Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation,” Journal of Immunology, vol. 172, no. 4, pp. 2586–2594, 2004. View at Google Scholar · View at Scopus
  13. Y. Chiba, Y. Yu, H. Sakai, and M. Misawa, “Increase in the expression of matrix metalloproteinase-12 in the airways of rats with allergic bronchial asthma,” Biological and Pharmaceutical Bulletin, vol. 30, no. 2, pp. 318–323, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. R. L. Warner, N. W. Lukacs, S. D. Shapiro et al., “Role of metalloelastase in a model of allergic lung responses induced by cockroach allergen,” American Journal of Pathology, vol. 165, no. 6, pp. 1921–1930, 2004. View at Google Scholar · View at Scopus
  15. Y. Yu, Y. Chiba, H. Sakai, and M. Misawa, “Effect of a matrix metalloproteinase-12 inhibitor, S-1, on allergic airway disease phenotypes in mice,” Inflammation Research, vol. 59, no. 6, pp. 419–428, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. E. López, V. Del Pozo, T. Miguel et al., “Inhibition of chronic airway inflammation and remodeling by Galectin-3 gene therapy in a murine model,” Journal of Immunology, vol. 176, no. 3, pp. 1943–1950, 2006. View at Google Scholar · View at Scopus
  17. K. S. Lee, K. H. Min, S. R. Kim et al., “Vascular endothelial growth factor modulates matrix metalloproteinase-9 expression in asthma,” American Journal of Respiratory and Critical Care Medicine, vol. 174, no. 2, pp. 161–170, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. D. G. Xisto, L. L. Farias, H. C. Ferreira et al., “Lung parenchyma remodeling in a murine model of chronic allergic inflammation,” American Journal of Respiratory and Critical Care Medicine, vol. 171, no. 8, pp. 829–837, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. N. R. Locke, S. G. Royce, J. S. Wainewright, C. S. Samuel, and M. L. Tang, “Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease,” American Journal of Respiratory Cell and Molecular Biology, vol. 36, no. 5, pp. 625–632, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. J. H. Ahn, C. H. Kim, Y. H. Kim et al., “Inflammatory and remodeling events in asthma with chronic exposure to house dust mites: a murine model,” Journal of Korean Medical Science, vol. 22, no. 6, pp. 1026–1033, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Fraga-Iriso, L. Núñez-Naveira, N. S. Brienza et al., “Development of a murine model of airway inflammation and remodeling in experimental asthma,” Archivos de Bronconeumologia, vol. 45, no. 9, pp. 422–428, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. T. Tsuchiya, Y. Nishimura, T. Nishiuma et al., “Airway remodeling of murine chronic antigen exposure model,” Journal of Asthma, vol. 40, no. 8, pp. 935–944, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Hayashi, W. G. Stetler-Stevenson, M. V. Fleming et al., “Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis,” American Journal of Pathology, vol. 149, no. 4, pp. 1241–1256, 1996. View at Google Scholar · View at Scopus
  24. D. Cataldo, C. Munaut, A. Noël et al., “MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease,” International Archives of Allergy and Immunology, vol. 123, no. 3, pp. 259–267, 2000. View at Google Scholar · View at Scopus
  25. R. D. Hautamaki, D. K. Kobayashi, R. M. Senior, and S. D. Shapiro, “Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice,” Science, vol. 277, no. 5334, pp. 2002–2004, 1997. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Molet, C. Belleguic, H. Lena et al., “Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease,” Inflammation Research, vol. 54, no. 1, pp. 31–36, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. D. W. Cockcroft and B. E. Davis, “Mechanisms of airway hyperresponsiveness,” Journal of Allergy and Clinical Immunology, vol. 118, no. 3, pp. 551–559, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. N. R. Locke, S. G. Royce, J. S. Wainewright, C. S. Samuel, and M. L. Tang, “Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease,” American Journal of Respiratory Cell and Molecular Biology, vol. 36, no. 5, pp. 625–632, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. D. H. Lim, Y. C. Jae, M. Miller, K. McElwain, S. McElwain, and D. H. Broide, “Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice,” American Journal of Physiology, vol. 291, no. 2, pp. L265–L271, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. L. J. McCawley and L. M. Matrisian, “Matrix metalloproteinases: they're not just for matrix anymore!,” Current Opinion in Cell Biology, vol. 13, no. 5, pp. 534–540, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Xia, D. Leppert, S. L. Hauser et al., “Stimulus specificity of matrix metalloproteinase dependence of human T cell migration through a model basement membrane,” Journal of Immunology, vol. 156, no. 1, pp. 160–167, 1996. View at Google Scholar · View at Scopus
  32. S. Okada, H. Kita, T. J. George, G. J. Gleich, and K. M. Leiferman, “Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9,” American Journal of Respiratory Cell and Molecular Biology, vol. 17, no. 4, pp. 519–528, 1997. View at Google Scholar · View at Scopus
  33. M. Vaalamo, A. L. Kariniemi, S. D. Shapiro, and U. Saarialho-Kere, “Enhanced expression of human metalloelastase (MMP-12) in cutaneous granulomas and macrophage migration,” Journal of Investigative Dermatology, vol. 112, no. 4, pp. 499–505, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. S. Nénan, J. M. Planquois, P. Berna et al., “Analysis of the inflammatory response induced by rhMMP-12 catalytic domain instilled in mouse airways,” International Immunopharmacology, vol. 5, no. 3, pp. 511–524, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus