Cardiac Ion Channelopathies and the Sudden Infant Death Syndrome
Figure 8
Prevalence of cardiac ion channelopathies in SIDS victims, based on data from population-based cohort studies (Tables 5 and 6). Blue bars indicate the prevalence of mutations and red bars that of mutations with a known malignant phenotype. (a) Mutations in genes affecting the fast sodium current . (b) Mutations in genes affecting the transient outward potassium current (KCND3), the slow delayed rectifier potassium current (KCNQ1 and KCNE1), the rapid delayed rectifier potassium current (KCNH2 and KCNE2), the inward rectifier potassium current (KCNJ2), the ATP-sensitive potassium current (KCNJ8), the RyR2 calcium release channel (RYR2), and the gap junctional current (GJA1).
