Reproducibility of Retinal Nerve Fiber Layer Measurements with Manual and Automated Centration in Healthy Subjects Using Spectralis Spectral-Domain Optical Coherence Tomography

Table 3

Overview published studies comparing RNFLT in SD-OCT.

Author	SD-OCT used	Study population (eyes)	Results
Leung et al. [6]	Cirrus and stratus	83 glaucoma; 97 controls	Cirrus: (95% CI); (i) repeatability 5.12 (3.87–6.37); (ii) CV 1.89% (1.43–2.36); (iii) ICC 0.975 (0.945–0.991); Stratus: (i) repeatability 11.10 (8.34–13.87); (ii) CV 3.58% (2.69–4.48); (iii) ICC 0.866 (0.741–0.933)
Vizzeri et al. [8]	Cirrus	78 glaucoma; 32 controls	Cirrus (95% CI); (i) Sw 1.3; (ii) CV 1.5%; (iii) ICC 0.96 (0.94–0.98)
Kim et al. [9]	Cirrus and stratus	27 controls	Cirrus (95% CI); ICC 0.984; Stratus; ICC 0.894
Gonzalez-Garcia et al. [10]	RTVue-100	76 glaucoma; 60 controls	RTVue (95% CI); (i) Sw 0.01; (ii) CV 0.27%; (iii) ICC 0.99 (0.98–0.99)
Seibold et al. [11]	Cirrus, Spectralis, RTVue-100, stratus	80 controls	Cirrus (95% CI); (i) Reproducibility 8.89 (5.75–12.02); (ii) CV 3.03% (1.47–4.03); (iii) ICC 0.92 (0.87–0.97); Spectralis; (i) Reproducibility 11.72 (9.31–14.13); (ii) CV 3.91% (2.81–4.77); (iii) ICC 0.90 (0.85–0.95); RTVue-100; (i) Reproducibility 6.59 (5.59–7.59); (ii) CV 2.09% (1.71–2.41); (iii)ICC 0.97 (0.96 to 0.98); Stratus; (i) Reproducibility 8.83 (7.21–10.45); (ii) CV 2.86% (2.17–3.42); (iii) ICC 0.94 (0.91 to 0.97)
Arthur et al. [12]	Spectralis	30 controls	Spectralis (95% CI); ICC 0.96 (0.94–0.99); Stratus; ICC 0.86 (0.77–0.94)
Langenegger et al. [14]	Spectralis	56 controls; 47 glaucoma	Spectralis (95% CI); (i) CV 1.0% with retest function; (ii) CV 1.6% without retest function; (iii) ICC 0.99 (0.98)
Serbecic et al. [15]	Spectralis	62 Controls	Spectralis (95% CI); CV 0.545–3.97%
Current study	Spectralis	39 controls	Spectralis (95% CI); (i) Reproducibility 1.30; (ii) CV 0.63%; (iii) ICC 0.983 (0.97–0.99)