Strain Echocardiography in Early Detection of Doxorubicin-Induced Left Ventricular Dysfunction in Children with Acute Lymphoblastic Leukemia

Table 4

Comparison between effects on patient group before and after doxorubicin on conventional echo and tissue Doppler parameters.

	Patient group before (𝑛-25)	Patient group after (𝑛-25)	𝑡-test	𝑃 value
FS %	40±4.87	33.5±6.58	2.508	0.02*
E (m/sec)	0.77±0.24	0.78±0.24	0.214	0.83
A (m/sec)	0.73±0.13	0.63±0.13	1.244	0.32
E/A	1.60±0.42	1.5±0.37	4.4	1.06
s (m/sec)	0.063±0.014	0.062±0.01	0.18	0.56
IVCT (ms)	86.5±4.2	85.9±0.8	2.4	0.02*
𝑒′ (m/sec)	0.127±0.011	0.132±0.009	1.099	0.26
𝑎′ (m/sec)	0.072±0.020	0.061±0.011	1.468	0.52
𝑒′/𝑎′	1.852±0.396	2.146±0.373	1.708	0.105
IVRT (ms)	67.1±3.28	7.1.8±3.28	5.8	<0.001*
ALX	−21.13±5.26%	−13.28±3.69%	3.859	0.001*
A4C	−18.91±4.51%	−17.27±4.19%	0.841	0.41
A2C	−16.87±7.25%	−14.75±3.56%	0.829	0.42
G	−18.65±4.52%	−15.10±2.45%	2.182	0.04*

FS: fractional shortening, 𝐸: peak early filling velocity, 𝐴: Peak atrial phase filling velocity, 𝑠′: tissue Doppler peak mitral annulus systolic velocity, 𝑒′: tissue Doppler mitral flow early-phase filling velocity, 𝑎′: tissue Doppler peak atrial phase filling velocity, IVCT: isometric contraction time, IVRTL: Isometric relaxation time, ALX: apical long axis, A4C: apical 4-chamber, A2C: apical 2-chamber, views, and 𝐺: global peak systolic strain.