Formulation and In Vitro Evaluation of Ufasomes for Dermal Administration of Methotrexate

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left"></td><td align="center">MTX (<i>μ</i>g)</td><td align="center">MTX (% age)</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">Aqueous control solution</td><td align="center"><svg height="12.2375" id="M28" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.2375" width="72.474998" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">5</tspan>
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<tspan style="font-size: 12.50px; " x="9.3772497" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">6</tspan>
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<tspan style="font-size: 12.50px; " x="45.373386" y="0">8</tspan>
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</svg>%</td><td align="center">13 ± 3</td></tr><tr><td align="left">carbopol gel</td><td align="center"><span style="width: 64.662498px;"><svg height="12.2375" id="M29" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 64.662498 12.2375" width="64.662498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">2</tspan>
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<tspan style="font-size: 12.50px; " x="35.996136" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">8</tspan>
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</svg></span></td><td align="center">30 ± 5</td></tr><tr><td align="left">UF-3</td><td align="center"><span style="width: 64.662498px;"><svg height="12.2375" id="M30" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 64.662498 12.2375" width="64.662498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">5</tspan>
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<tspan style="font-size: 12.50px; " x="35.996136" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="42.247639" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">5</tspan>
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</svg></span></td><td align="center">43 ± 4</td></tr><tr><td align="left">UF gel</td><td align="center"><span style="width: 72.474998px;"><svg height="12.2375" id="M31" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.2375" width="72.474998" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">9</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="15.62875" y="0">5</tspan>
<tspan style="font-size: 12.50px; " x="21.880251" y="0">5</tspan>
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<tspan style="font-size: 12.50px; " x="42.247639" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="48.499138" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">3</tspan>
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</svg></span></td><td align="center">52 ± 6</td></tr><tr><td align="left">UF suspension</td><td align="center"><span style="width: 72.474998px;"><svg height="12.2375" id="M32" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.2375" width="72.474998" xmlns="http://www.w3.org/2000/svg">
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<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">9</tspan>
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<tspan style="font-size: 12.50px; " x="42.247639" y="0">4</tspan>
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<tspan style="font-size: 12.50px; " x="51.624886" y="0">6</tspan>
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</svg></span></td><td align="center">45 ± 5</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

% Cumulative amount of methotrexate permeated after 24 h (microgram MTX) and skin deposition (percentage MTX) from different vesicular formulations and from aqueous control solution.

International Scholarly Research Notices

tab2

Table 2

Table 2: Formulation and In Vitro Evaluation of Ufasomes for Dermal Administration of Methotrexate 