Formulation and In Vitro Evaluation of Ufasomes for Dermal Administration of Methotrexate

Table 3

Order of drug release of various formulations determined by the regression coefficients.

Formulation	** r^2				^4*n
	Zero order	First order	Higuchi	^3*Log k
UF-3 gel	0.9961	0.8843	0.9792	0.7327	0.7574
UF-3	0.9742	0.7931	0.9534	0.8143	0.8304
Carbopol gel	0.8227	0.9964	0.9346	0.9923	0.9953
Plain drug	0.6081	0.9582	0.8687	1.2465	1.2314

^∗∗Coefficient of correlation, ^3∗kinetic constant, and ^4∗diffusional exponent indicative of the mechanism of drug release.