Table of Contents
ISRN Pathology
Volume 2012 (2012), Article ID 873759, 5 pages
http://dx.doi.org/10.5402/2012/873759
Research Article

Investigation of Tenascin Expression in Endometriosis

1Department of Obstetrics and Gynecology, School of Medicine, Firat University, 23119 Elazig, Turkey
2Department of Pathology, School of Medicine, Firat University, 23119 Elazig, Turkey
3Department of Biochemistry, School of Medicine, Firat University, 23119 Elazig, Turkey

Received 17 November 2012; Accepted 9 December 2012

Academic Editors: A. Gocht, A.-J. Kruse, and A. Stringer

Copyright © 2012 Zehra Sema Ozkan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate the serum and tissue levels and local expression pattern of tenascin, a high molecular weight extracellular matrix protein, in eutopic and ectopic endometrium from patients with and without endometriosis and to compare the proliferative and secretory phase differences. Materials and Methods. Thirty women with endometriosis and fifteen women without endometriosis undergoing surgery for benign indications were included in the study. Serum and tissue levels and proliferative and secretory phase expression patterns of tenascin in the ectopic and eutopic endometrium were analyzed with immunohistochemistry and immunoassays. The results were compared with Mann-Whitney U test. values <0.05 were considered as statistically significant. Results. Tenascin expression was detected in both of eutopic and ectopic endometrium of women with and without endometriosis. In immunohistochemical staining, intense staining of tenascin was observed in glandular cells of eutopic and ectopic endometrial tissue samples of both groups during secretory phase ( ). Eutopic and ectopic tissue levels of tenascin were higher than serum tenascin levels only secretory phase ( ). There was no significant difference between groups for tissue and serum levels of tenascin during cycle phases. Conclusion. Tenascin expression showed cyclic change on eutopic and ectopic endometrium.