International Scholarly Research Notices / 2012 / Article / Tab 2

Clinical Study

Evaluation of Acute Locoregional Toxicity in Patients with Breast Cancer Treated with Adjuvant Radiotherapy in Combination with Pazopanib

Table 2

Acute locoregional toxicity of concurrent Pazopanib + RT versus RT alone scored using CTCAE.

Locoregional
toxicity
Pazopanib + RTRT Alone
Grade 1-2 Grade 3–5 Grade 1-2Grade 3–5
n affected (total)n affected (total) n affected (total)n affected (total)

Fatigue12 (12)0 (12)25 (25)0 (25)
Dermatitis radiation12 (12)0 (12)21 (19)4 (25)
Skin hyperpigmentation2 (12)0 (12)15 (25)0 (25)
Skin ulceration1 (12)0 (12)0 (25)0 (25)
Soft tissue fibrosis0 (12)0 (12)0 (25)0 (25)
Pneumonitis0 (12)0 (12)0 (25)0 (25)
Diarrhea3 (12)0 (12)0 (25)0 (25)
Hypertension1 (12)0 (12)0 (25)0 (25)
Nausea2 (12)0 (12)0 (25)0 (25)
Anorexia1 (12)1 (12)0 (25)0 (25)

RT: radiotherapy; CTCAE: Common Terminology Criteria for Adverse Events (v4.0).