Table of Contents
ISRN Anesthesiology
Volume 2012 (2012), Article ID 905034, 5 pages
http://dx.doi.org/10.5402/2012/905034
Research Article

Utilization of a Swine (Sus scrofa) Model for Lipid Emulsion Resuscitation Studies

AMEDD Center and School, Academy of Health Sciences Graduate School, 3490 Forage Road, Dunlap Hall, Fort Sam Houston, TX 78234, USA

Received 24 September 2012; Accepted 5 November 2012

Academic Editors: J. P. Estebe, D. Karakaya, A. Mizutani, D. E. Raines, and A. Wiebalck

Copyright © 2012 Carrie Crane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Ludot, J. Y. Tharin, M. Belouadah, J. X. Mazoit, and J. M. Malinovsky, “Successful resuscitation after ropivacaine and lidocaine-induced ventricular arrhythmia following posterior lumbar plexus block in a child,” Anesthesia and Analgesia, vol. 106, no. 5, pp. 1572–1574, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. S. D. H. Finn, D. R. Uncles, J. Willers, and N. Sable, “Early treatment of a quetiapine and sertraline overdose with Intralipid®,” Anaesthesia, vol. 64, no. 2, pp. 191–194, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. A. J. Sirianni, K. C. Osterhoudt, D. P. Calello et al., “Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine,” Annals of Emergency Medicine, vol. 51, no. 4, pp. 412–415.e1, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Foxall, R. Mccahon, J. Lamb, J. G. Hardman, and N. M. Bedforth, “Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid,” Anaesthesia, vol. 62, no. 5, pp. 516–518, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Harvey, G. Cave, and A. Kazemi, “Intralipid infusion diminishes return of spontaneous circulation after hypoxic cardiac arrest in rabbits,” Anesthesia and Analgesia, vol. 108, no. 4, pp. 1163–1168, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Markowitz and J. M. Neal, “Immediate lipid emulsion therapy in the successful treatment of bupivacaine systemic toxicity,” Regional Anesthesia and Pain Medicine, vol. 34, no. 3, p. 276, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Weinberg, “Lipid rescue resuscitation from local anaesthetic cardiac toxicity,” Toxicological Reviews, vol. 25, no. 3, pp. 139–145, 2006. View at Google Scholar · View at Scopus
  8. L. Rothschild, S. Bern, S. Oswald, and G. Weinberg, “Intravenous lipid emulsion in clinical toxicology,” Scandinavian Journal of Trauma, Resuscitation, and Emergency Medicine, vol. 18, article 51, 2010. View at Google Scholar · View at Scopus
  9. F. Dorandeu, J. R. Mikler, H. Thiermann et al., “Swine models in the design of more effective medical countermeasures against organophosphorus poisoning,” Toxicology, vol. 233, no. 1–3, pp. 128–144, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Szebeni, “Complement activation-related pseudoallergy caused by liposomes, micellar carriers of intravenous drugs, and radiocontrast agents,” Critical Reviews in Therapeutic Drug Carrier Systems, vol. 18, no. 6, pp. 567–606, 2001. View at Google Scholar · View at Scopus
  11. J. Szebeni, “Complement activation-related pseudoallergy: a new class of drug-induced acute immune toxicity,” Toxicology, vol. 216, no. 2-3, pp. 106–121, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Szebeni, C. R. Alving, L. Rosivall et al., “Animal models of complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanoparticles,” Journal of Liposome Research, vol. 17, no. 2, pp. 107–117, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Szebeni, L. Baranyi, S. Sávay et al., “Complement activation-related cardiac anaphylaxis in pigs: role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function,” American Journal of Physiology, vol. 290, no. 3, pp. H1050–H1058, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. B. Zider and G. Weinberg, “Are pigs the right model for lipid resuscitation?” AANA Journal, vol. 79, no. 6, pp. 453–454, e453. View at Google Scholar
  15. The Association of Anaesthetists of Great Britain and Ireland 2010, Guidelines for the Management of Sever Local Anaesthetic Toxcity, 2012, http://www.aagbi.org/sites/default/files/la_toxicity_2010_0.pdf.
  16. G. Weinberg, “Lipid rescue: caveats and recommendations for the ‘Silver Bullet’,” Regional Anesthesia and Pain Medicine, vol. 29, pp. 74–75, 2004. View at Google Scholar
  17. R. J. Litz, M. Popp, S. N. Stehr, and T. Koch, “Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion,” Anaesthesia, vol. 61, no. 8, pp. 800–801, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. M. A. Rosenblatt, M. Abel, G. W. Fischer, C. J. Itzkovich, and J. B. Eisenkraft, “Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest,” Anesthesiology, vol. 105, no. 1, pp. 217–218, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. X. Caide, Z. Liu, Q. Gao, Q. Zhou, and S. F. Sui, “Specific interaction of rabbit C-reactive protein with phospholipid membranes,” Thin Solid Films, vol. 284-285, pp. 793–796, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. D. B. Hiller, G. Di Gregorio, K. Kelly et al., “Safety of high volume lipid emulsion infusion: a first approximation of LD50 in rats,” Regional Anesthesia and Pain Medicine, vol. 35, no. 2, pp. 140–144, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Buhl, J. Gjedsted, A. Granfeldt et al., “Circulating free fatty acids do not contribute to the acute systemic inflammatory response. An experimental study in porcine endotoxaemia,” Basic and Clinical Pharmacology and Toxicology, vol. 105, no. 5, pp. 319–326, 2009. View at Publisher · View at Google Scholar · View at Scopus