Table of Contents
ISRN Chromatography
Volume 2012 (2012), Article ID 916932, 8 pages
http://dx.doi.org/10.5402/2012/916932
Research Article

Development and Validation of Stability-Indicating RP-UPLC Method for the Determination of Methdilazine in Bulk Drug and in Pharmaceutical Dosage Form

Department of Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India

Received 6 August 2012; Accepted 12 September 2012

Academic Editors: A. Namera, A. Sanches Silva, and A. I. Suarez

Copyright © 2012 Madihalli S. Raghu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. The Merck Index, Merck Research Laboratories, Martindale, Merck, 13th edition, 2001.
  2. M. Gordon, Ed., PsychoPharmacological Agents, vol. 2, Academic Press, New York, NY, USA, 1994.
  3. “The United States Pharmacopoeia XXIV Revision,” The National Formulary XIX Rockville, USP Convention, 2000.
  4. R. T. Sane, L. S. Joshi, R. M. Kothurkar, K. D. Ladage, R. V. Tendolkar, and D. P. Gangal, “HPLC determination of methdilazine HCl in pharmaceutical dosage forms,” Indian Journal of Pharmaceutical Sciences, vol. 52, no. 3, pp. 160–161, 1990. View at Google Scholar · View at Scopus
  5. K. Croes, P. T. McCarthy, and R. J. Flanagan, “HPLC of basic drugs and quaternary ammonium compounds on microparticulate strong cation-exchange materials using methanolic or aqueous methanol eluents containing an ionic modifier,” Journal of Chromatography A, vol. 693, no. 2, pp. 289–306, 1995. View at Publisher · View at Google Scholar · View at Scopus
  6. N. W. Smith and M. B. Evans, “The efficient analysis of neutral and highly polar pharmaceutical compounds using reversed-phase and ion-exchange electrochromatography,” Chromatographia, vol. 41, no. 3, pp. 197–203, 1995. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Y. Mohammed and F. F. Cantwell, “Liquid chromatographie analysis of pharmaceutical syrups using pre-columns and salt-adsorption on amberlite XAD-2,” Analytical Chemistry, vol. 50, no. 3, pp. 491–496, 1978. View at Google Scholar · View at Scopus
  8. C. S. P. Sastry, A. S. R. Prasad Tipirneni, M. V. Suryanarayana, T. Thirupathi Rao, and T. Satyanarayana, “Spectrofluorimetric determination of trimeprazine tartrate and methdilazine hydrochloride in formulations,” Indian Journal of Pharmaceutical Sciences, vol. 52, no. 2, pp. 115–117, 1990. View at Google Scholar · View at Scopus
  9. D. F. Gurka, R. E. Kolinski, J. W. Myrick, and C. E. Wells, “Scope of differential UV and differential fluorescence assays for phenothiazines: comparison with official methods,” Journal of Pharmaceutical Sciences, vol. 69, no. 9, pp. 1069–1074, 1980. View at Google Scholar · View at Scopus
  10. J. Emmanuel and R. Mathew, “Spectrophotometric determination of methdilazine hydrochloride in pharmaceutical formulations,” Indian Drugs, vol. 22, pp. 602–605, 1985. View at Google Scholar
  11. C. S. P. Sastry, A. S. R. P. Tipirneni, and M. V. Suryanarayana, “Spectrophotometric determination of trimeprazine and methdilazine with sodium cobaltinitrite,” Eastern Pharmacist, vol. 32, pp. 131–133, 1989. View at Google Scholar
  12. C. S. P. Sastry, A. S. R. P. Tipirneni, and M. V. Suryanarayana, “Sensitive spectrophotometric determination of some antihistamines with haematoxylin and chloramines-T,” Indian Drugs, vol. 36, pp. 351–357, 1989. View at Google Scholar
  13. C. S. P. Sastry, A. S. R. P. Tipirneni, and M. V. Suryanarayana, “Spectrophotometric determination of some antiallergic agents with 3-methyl-2-benzothiazolinone hydrazone,” Journal of Pharmaceutical and Biomedical Analysis, vol. 8, no. 3, pp. 287–289, 1990. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Basavaiah and V. S. Charan, “Visible spectrophotometric determination of methdilazine in dosage forms using metavanadate and H2O2,” Indian Drugs, vol. 39, no. 8, pp. 449–451, 2002. View at Google Scholar · View at Scopus
  15. K. Basavaiah and V. S. Charan, “Four new vanadometric methods for the assay of methdilazine in bulk drug and in pharmaceutical formulations,” Science Asia, vol. 29, pp. 37–44, 2003. View at Google Scholar
  16. K. Basavaiah and V. S. Charan, “Four simple procedures for the assay of methdilazine in bulk drug and in tablets and syrup using potassium iodate,” Farmaco, vol. 58, no. 4, pp. 285–292, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Basavaiah and V. S. Charan, “The use of chloranilic acid for the spectrophotometric determination of three antihistamines,” Turkish Journal of Chemistry, vol. 26, no. 5, pp. 653–661, 2002. View at Google Scholar · View at Scopus
  18. B. G. Gowda and J. Seetharamappa, “Extractive spectrophotometric determination of fluoroquinolones and antiallergic drugs in pure and pharmaceutical formulations,” Analytical Sciences, vol. 19, no. 3, pp. 461–464, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. K. C. Ramesh, B. G. Gowda, M. B. Melwanki, J. Seetharamappa, and J. Keshavayya, “Extractive spectrophotometric determination of antiallergic drugs in pharmaceutical formulations using bromopyrogallol red and bromothymol blue,” Analytical Sciences, vol. 17, no. 9, pp. 1101–1103, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. C. S. P. Sastry, T. A. S. R. Prasad, and M. V. Suryanarayana, “Extraction-spectrophotometric determination of some antihistaminic agents with fast green FCF,” Mikrochimica Acta, vol. 100, no. 1-2, pp. 107–112, 1990. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Basavaiah and V. S. Charan, “Spectrophotometric and turbidimetric determination of methdilazine using bromophenol blue,” Indian Pharmacist, pp. 97–100, 2003. View at Google Scholar
  22. C. S. P. Sastry, A. S. R. Prasad Tipirneni, and M. V. Suryanarayana, “Spectrophotometric determination of some antihistamines with cobalt thiocyanate,” Indian Journal of Pharmaceutical Sciences, vol. 51, no. 4, pp. 146–148, 1989. View at Google Scholar · View at Scopus
  23. S. Singh, B. Singh, R. Bahuguna, L. Wadhwa, and R. Saxena, “Stress degradation studies on ezetimibe and development of a validated stability-indicating HPLC assay,” Journal of Pharmaceutical and Biomedical Analysis, vol. 41, no. 3, pp. 1037–1040, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Mohammadi, I. Haririan, N. Rezanour, L. Ghiasi, and R. B. Walker, “A stability-indicating high performance liquid chromatographic assay for the determination of orlistat in capsules,” Journal of Chromatography A, vol. 1116, no. 1-2, pp. 153–157, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. I. Ivana, Z. Ljiljana, and Z. Mira, “A stability indicating assay method for cefuroxime axetil and its application to analysis of tablets exposed to accelerated stability test conditions,” Journal of Chromatography A, vol. 1119, no. 1-2, pp. 209–215, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. K. B. Vinay, H. D. Revanasiddappa, C. M. Xavier, P. J. Ramesh, and M. S. Raghu, “A stability indicating uplc method for the determination of tramadol hydrochloride: application to pharmaceutical analysis,” Chromatography Research International, vol. 2012, Article ID 870951, 9 pages, 2012. View at Publisher · View at Google Scholar
  27. “Stability testing of new drug substances and products,” in Proceedings of the International Conference on Harmonization Q1A (R2), IFPMA, Geneva, Switzerland, 2006.
  28. L. Nováková, L. Matysová, and P. Solich, “Advantages of application of UPLC in pharmaceutical analysis,” Talanta, vol. 68, no. 3, pp. 908–918, 2006. View at Publisher · View at Google Scholar · View at Scopus