Senescence-Accelerated Mice P8: A Tool to Study Brain Aging and Alzheimer's Disease in a Mouse Model

Table 3

Molecular and cellular pathways altered in SAMP8.

Pathway/protein target	Modification	Reference
Sirtuin 1	Decreased	[20, 58, 97]
Autophagic process	Reduced	[117–119]
Cathepsin system	Inactivated	[117]
AMPK	Not determined
mTOR	Not determined
mtDNA damage	Increased	[125]
Mitochondrial electron chain	Diminished efficiency	[20, 21, 29, 126, 127]
Fusion/fission proteins	Not determined
Mitochondrial fatty acid oxidation	Altered	[128]