Figure 1: PINK1 and Parkin proteins. MTS, mitochondrial targeting sequence; TM, transmembrane domain; Ubl, ubiquitin-like domain; RING, Ring finger motif; IBR, in between RING fingers domain. RING0 has been characterized as a new domain with a similarity to conventional RING1 and RING2 domains [42]. The numbers correspond to the residue numbers for boundaries of the indicated domains.