The Role of the Immune System in Nevirapine-Induced Subclinical Liver Injury of a Rat Model
Table 3
Full blood count data (mean ± SD) for groups of animals () after 21 days of dosing with saline and nevirapine (S + NVP) and lipopolysaccharide and nevirapine (LPS + NVP).
S + NVP
LPS + NVP
Reference range
Red blood cells
Red cell count
8.91 ± 0.4
9.08 ± 0.1
4.5–5.9 × 1012/L
Haemoglobin
16.70 ± 0.7
16.93 ± 0.5
13.0–18.0 g/dL
Haematocrit
0.74 ± 0.0
0.73 ± 0.0
0.40–0.50 L/L
MCV
83.33 ± 1.2
83.0 ± 1.0
81–100 fL
MCH
19 ± 0.0
19.0 ± 0.5
28–35 pg
MCHC
22.3 ± 0.6
22.7 ± 0.6
32–36 g/dL
White blood cells
White cell count
10.90 ± 0.5
15.33 ± 2.1
4.0–11.0 × 109/L
Neutrophils
2.22 ± 0.6
8.89 ± 1.3
2.0–7.50 × 109/L
Lymphocytes
7.95 ± 1.4
5.33 ± 1.1
1.0–4.00 × 109/L
Monocytes
0.59 ± 0.1
0.74 ± 0.5
0.0–0.95 × 109/L
Eosinophils
0.10 ± 0.0
0.57 ± 0.5
0.0–0.40 × 109/L
Basophils
0.10 ± 0.0
0.00 ± 0.0
0.0–0.10 × 109/L
Others
Platelet count
975 ± 184
601 ± 85.4
140–420 × 109/L
Key: S: saline, NVP: nevirapine, LPS: lipopolysaccharide, MCV: mean corpuscular volume, MCH: mean corpuscular haemoglobin, and MCHC: mean corpuscular haemoglobin concentration.
