Table of Contents
ISRN Pharmacology
Volume 2012, Article ID 941068, 6 pages
http://dx.doi.org/10.5402/2012/941068
Research Article

Evaluation of Oxidative Stress and Antioxidant Status in Patients with Cardiovascular Disease in Rural Populations of the Nilgiris, South India

1Department of Pharmacology, JSS College of Pharmacy, Ootacamund 643001, India
2Department of Pharmacy Practise, JSS College of Pharmacy, Ootacamund 643001, India

Received 29 November 2011; Accepted 20 December 2011

Academic Editors: G. M. Campo and R. Fantozzi

Copyright © 2012 E. P. Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The objective of this work was to study the risk factors of ischaemic heart disease (IHD) in rural populations of the Nilgiris, south India, with stress on the various social habits and oxidant stress. Methods. A total of 72 patients with cardiovascular disease (CVD) and 12 healthy volunteers were screened. Forty-seven patients with CVD (intervention group) and 10 healthy volunteers (control group) were randomly selected for the study. Written informed consent was obtained from all the participants, and their demographic details were collected. A 6 mL blood sample was collected from each of the participants, and the serum was separated in the samples. The levels of enzymic (superoxide dismutase, catalase) and nonenzymic antioxidants (ascorbic acid) in the plasma were determined biochemically. The level of thiobarbituric acid species (TBARS), which is a predictor of lipid peroxidation, was measured. Results. The participants of the study were stratified as according to demographic and social variables. The values of all the antioxidants and TBARS were statistically compared. Significantly reduced antioxidant levels and increased TBARS levels were found in the intervention group compared with the control group. The results suggest that the lowered antioxidant level may be a result of the oxidant stress of the disease. Statistically significant differences were not found in the antioxidant and TBARS levels when comparing smokers versus nonsmokers, alcoholics versus nonalcoholics, and vegetarians versus nonvegetarians. Conclusion. The major causes of CVD amongst the rural populations of the Nilgiris, south India, are preventable causes such as smoking and high fat intake, all of which cause oxidative stress, as seen in our study through various serum markers.