T-817MA, but Not Haloperidol and Risperidone, Restores Parvalbumin-Positive γ-Aminobutyric Acid Neurons in the Prefrontal Cortex and Hippocampus of Rats Transiently Exposed to MK-801 at the Neonatal Period

Figure 2

Effect of 14-day (PD 49–62) treatment with T-817MA, HPD or RPD on the density of PV-positive GABAergic interneurons (cells/mm²) in the mPFC. Data from DW group (𝑛=11), HPD group (𝑛=11), RPD group (𝑛=10), and T-817MA group (𝑛=11) treated neonatally with saline are shown in the left side. Data from DW group (𝑛=9), HPD group (𝑛=10), RPD group (𝑛=11), and T-817MA group (𝑛=9) treated neonatally with MK-801 are shown in the right side. Values are expressed as means ± SEM. ^#; 𝑃<0.05 as compared with saline-DW group. *; 𝑃<0.05 as compared with MK-801-DW group. (b) Representative photomicrographs of PV-positive neurons in the mPFC from rats on PD 63.

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