Table of Contents
ISRN Pharmacology
Volume 2012 (2012), Article ID 950603, 5 pages
http://dx.doi.org/10.5402/2012/950603
Research Article

Abnormal Movements of Japanese Infants following Treatment with Midazolam in a Neonatal Intensive Care Unit: Incidence and Risk Factors

1Department of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan
2Neonatal Medical Center, Kumamoto City Hospital, 1-1-60 Kotoh, Kumamoto 862-8505, Japan
3Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan

Received 31 January 2012; Accepted 19 February 2012

Academic Editors: H. Y. Lane and T. B. Vree

Copyright © 2012 Mitsuru Irikura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Carbajal, A. Rousset, C. Danan et al., “Epidemiology and treatment of painful procedures in neonates in intensive care units,” Journal of the American Medical Association, vol. 300, no. 1, pp. 60–70, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. K. J. S. Anand, “Pharmacological approaches to the management of pain in the neonatal intensive care unit,” Journal of Perinatology, vol. 27, no. 1, pp. S4–S11, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Fitzgerald, A. Shaw, and N. MacIntosh, “Postnatal development of the cutaneous flexor reflex: comparative study of preterm infants and newborn rat pups,” Developmental Medicine and Child Neurology, vol. 30, no. 4, pp. 520–526, 1988. View at Google Scholar · View at Scopus
  4. K. J. S. Anand, “Pain, plasticity, and premature birth: a prescription for permanent suffering?” Nature Medicine, vol. 6, no. 9, pp. 971–973, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. K. S. Anand, R. E. Grunau, and T. F. Oberlander, “Developmental character and long-term consequences of pain in infants and children,” Child and Adolescent Psychiatric Clinics of North America, vol. 6, no. 4, pp. 703–724, 1997. View at Google Scholar · View at Scopus
  6. J. W. B. Peters, R. Schouw, K. J. S. Anand, M. Van Dijk, H. J. Duivenvoorden, and D. Tibboel, “Does neonatal surgery lead to increased pain sensitivity in later childhood?” Pain, vol. 114, no. 3, pp. 444–454, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. M. A. Ruda, Q. D. Ling, A. G. Hohmann, Y. B. Peng, and T. Tachibana, “Altered nociceptive neuronal circuits after neonatal peripheral inflammation,” Science, vol. 289, no. 5479, pp. 628–630, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Bartocci, L. L. Bergqvist, H. Lagercrantz, and K. J. S. Anand, “Pain activates cortical areas in the preterm newborn brain,” Pain, vol. 122, no. 1-2, pp. 109–117, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Lago, A. Guadagni, D. Merazzi, G. Ancora, C. V. Bellieni, and A. Cavazza, “Pain management in the neonatal intensive care unit: a national survey in Italy,” Paediatric Anaesthesia, vol. 15, no. 11, pp. 925–931, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. B. Gharavi, C. Schott, M. Nelle, G. Reiter, and O. Linderkamp, “Pain management and the effect of guidelines in neonatal units in Austria, Germany and Switzerland,” Pediatrics International, vol. 49, no. 5, pp. 652–658, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. J. N. Van den Anker and P. J. J. Sauer, “The use of midazolam in the preterm neonate,” European Journal of Pediatrics, vol. 151, no. 2, p. 152, 1992. View at Google Scholar · View at Scopus
  12. J. F. Magny, A. M. d'Alest, H. Nedelcoux, V. Zupan, and M. Dehan, “Midazolam and mycclonus in neonate,” European Journal of Pediatrics, vol. 153, no. 5, pp. 389–390, 1994. View at Google Scholar · View at Scopus
  13. J. Hughes, A. Gill, H. J. Leach et al., “A prospective study of the adverse effects of midazolam on withdrawal in critically ill children,” Acta Paediatrica, vol. 83, no. 11, pp. 1194–1199, 1994. View at Google Scholar · View at Scopus
  14. D. Waisman, Z. Weintraub, A. Rotschild, and Y. Bental, “Myoclonic movements in very low birth weight premature infants associated with midazolam intravenous bolus administration,” Pediatrics, vol. 104, no. 3, p. 579, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Burtin, E. Jacqz-Aigrain, P. Girard et al., “Population pharmacokinetics of midazolam in neonates,” Clinical Pharmacology and Therapeutics, vol. 56, no. 6, pp. 615–625, 1994. View at Google Scholar · View at Scopus
  16. T. C. Lee, B. G. Charles, G. J. Harte, P. H. Gray, P. A. Steer, and V. J. Flenady, “Population pharmacokinetic modeling in very premature infants receiving midazolam during mechanical ventilation: midazolam neonatal pharmacokinetics,” Anesthesiology, vol. 90, no. 2, pp. 451–457, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Jacqz-Aigrain, C. Wood, and I. Robieux, “Pharmacokinetics of midazolam in critically ill neonates,” European Journal of Clinical Pharmacology, vol. 39, no. 2, pp. 191–192, 1990. View at Publisher · View at Google Scholar · View at Scopus