Plasma Disposition of Conventional and Long-Acting Moxifloxacin in Sheep after Intravenous Administration

Table 1

Plasma concentrations of conventional long acting moxifloxacin after single-dose intravenous administration in male sheep.

Time after drug administration (h)	Long acting moxifloxacin concentration (𝜇g·mL^−1)	Conventional moxifloxacin concentration (𝜇g·mL^−1)
0.083	7.227 ± 0.130	9.917 ± 0.902
0.166	5.646 ± 0.044	5.596 ± 0.092
0.5	4.283 ± 0.220	3.887 ± 0.278
1	2.853 ± 0.136	2.496 ± 0.007
2	2.230 ± 0.055	1.529 ± 0.111
4	1.711 ± 0.077	0.544 ± 0.012
8	0.772 ± 0.022	0.224 ± 0.019
12	0.368 ± 0.019	0.067 ± 0.008
24	0.150 ± 0.002	0.015 ± 0.005
36	0.076 ± 0.002
48	0.043 ± 0.001
60	0.026 ± 0.001
72	0.016 ± 0.002
96	ND

ND: not detectable; figures of moxifloxacin concentrations are in mean ± S.E.