Table of Contents
ISRN Oncology
Volume 2012, Article ID 957835, 9 pages
Review Article

Optical Detection of Preneoplastic Lesions of the Central Airways

1Department of Respiratory Diseases, Erasmus Medical Center, Postbus 2040, 3000 CA Rotterdam, The Netherlands
2Department of Respiratory Diseases, Amphia Hospital, Molengracht 21, 4818 CK Breda, The Netherlands
3Center for Optical Diagnostics and Therapy and Department of Radiation Oncology, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands

Received 27 December 2011; Accepted 16 January 2012

Academic Editors: P. Clavère and L. Mutti

Copyright © 2012 C. van der Leest et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Current routine diagnosis of premalignant lesions of the central airways is hampered due to a limited sensitivity (white light bronchoscopy) and resolution (computer tomography (CT), positron emission tomography (PET)) of currently used techniques. To improve the detection of these subtle mucosal abnormalities, novel optical imaging bronchoscopic techniques have been developed over the past decade. In this review we highlight the technological developments in the field of endoscopic imaging, and describe their advantages and disadvantages in clinical use.