Research Article

Prevalence of HIV-Associated Metabolic Abnormalities among Patients Taking First-Line Antiretroviral Therapy in Uganda

Table 3

Prevalence of dyslipidemia and hyperglycemia in HIV-infected patients according to stavudine- and zidovudine-containing regimens.

StavudineZidovudine Total
Lipid abnormalities 𝑁 = 2 0 8 𝑁 = 2 1 5 𝑁 = 4 2 3 𝑃 value
𝑁 (%) 𝑁 (%) 𝑁 (%)

Total cholesterol
 Borderline58 (27.9)48 (22.3)106 (25.1)0.018 
 High35 (16.8)24 (11.2)59 (14.0)
LDL-cholesterol
 Borderline29 (13.9)17 (7.9)46 (10.9)0.013
 High22 (10.6)15 (7.0)37 (44.6)
Triglycerides
 Borderline40 (19.2)31 (14.4)71 (16.8)0.025 
 High19 (9.1)10 (4.7)29 (6.9)
HDL-cholesterol
 Borderline147 (70.7)87 (40.5)234 (55.3) < 0.001
 Low12 (5.8)7 (3.3)19 (4.5)
Dyslipidemia
 Borderline190 (91.4)155 (72.1)345 (81.6) < 0.001
 Overt46 (22.1)34 (15.8)80 (18.9)
Hyperglycemia
 Borderline23 (11.1)38 (17.7)61 (14.4)
 Overt6 (2.9)11 (5.1)17 (4.0)

TC: total cholesterol; LDL: low-density lipoprotein; HDL: high-density lipoprotein.