Effects of a Physical Activity Program on Markers of Endothelial Dysfunction, Oxidative Stress, and Metabolic Status in Adolescents with Metabolic Syndrome

Table 4

Effects of PA on markers of inflammation, endothelial dysfunction, and stress oxidative in adolescents.

	Women (𝑛=18) (mean ± SD)						Men (𝑛=20) (mean ± SD)
	With MetS			Without MetS			With MetS			Without MetS
	Basal	PPA	𝑃^∗	Basal	PPA	𝑃^∗	Basal	PPA	𝑃^∗	Basal	PPA	𝑃^∗
Markers of inflammation
hsCRP	0.16 (0.14)	0.13 (0.14)	0.618	0.07 (0.04)	0.05 (0.04)	0.467	0.09 (0.06)	0.12 (0.10)	0.393	0.13 (0.08)	0.11 (0.09)	0.572
Fg	457 (138)	256 (78)	0.009	377 (163)	361 (113)	0.876	438 (178)	267 (55)	0.017	418 (141)	307 (52)	0.050
FVIII	121 (24)	96 (14)	0.016	112 (32)	83 (26)	0.127	112 (27)	104 (19)	0.048	137 (43)	91 (19)	0.045
Markers of endothelial cell damage
PAI-1	37.2 (11.6)	22.2 (9.5)	0.042	27.3 (8.9)	22.7 (4.9)	0.307	38.9 (5.9)	20.8 (8.4)	0.002	38.9 (10)	25.9 (8.6)	0.041
tPA	5.8 (2.9)	8.6 (3.3)	0.038	3.3 (1.3)	5.4 (3.5)	0.107	4.4 (1.9)	7.9 (4.3)	0.013	4.9 (2.4)	9.2 (3.4)	0.054
vWF	144 (27)	139 (35)	0.685	128 (28)	110 (38)	0.225	146 (26)	119 (50)	0.231	151 (37)	129 (37)	0.328
sVCAM-1	17.4 (6.1)	12.1 (2.8)	0.025	22.8 (13.7)	11.7 (2.7)	0.118	26.9 (17.8)	13.1 (3.8)	0.045	19.9 (5.6)	13.0 (2.3)	0.019
P-selectin	24.4 (4.8)	18.4 (9.1)	0.051	20.0 (5.3)	10.0 (3.9)	0.005	22.5 (10)	12.8 (5.4)	0.028	24.1 (8.9)	14.9 (7.2)	0.018
Markers of oxidative stress
Lpox	518 (119)	371 (50)	0.022	574 (107)	394 (39)	0.089	611 (215)	354 (65)	0.002	448 (144)	388 (42)	0.324
SOD	341 (237)	800 (393)	0.032	778 (276)	681 (484)	0.757	697 (390)	803 (315)	0.487	655 (809)	719 (302)	0.825
Cat	16.8 (13.3)	9.2 (17.9)	0.405	26.1 (17.2)	5.8 (3.2)	0.118	16.5 (16.0)	9.8 (19.6)	0.500	15.4 (9.5)	3.6 (4.1)	0.037
Gpox	964 (1282)	3137 (5713)	0.308	208 (103)	3126 (3549)	0.202	2349 (2519)	3055 (4397)	0.714	4588 (4436)	1333 (722)	0.164
SOD/Gpox + Cat	17.8 (13.5)	10.0 (17.9)	0.387	31.1 (18.5)	6.2 (3.5)	0.087	17.3 (16.1)	10.5 (20.6)	0.496	17.7 (12.7)	4.7 (3.9)	0.064

PPA: postphysical activity; hsCRP: high-sensitivity C-reactive protein (mg/dL); Fg: fibrinogen (mg/dL); PAI-1: plasminogen activator inhibitor type 1 (ng/mL); tPA: tissue plasminogen activator (ng/mL); vWF: von Willebrand factor (UI/mL); FVIII: factor VIII (%); sVCAM-1: soluble vascular cell adhesion molecule-1 (U/mL); P-selectin (U/mL); Lpox: lipoperoxidation (nMol MDA/gHb); SOD: superoxide dismutase (μMol adrenalin/gHb); Cat: catalase (μMol H₂O₂/gHb); Gpox: glutathione peroxidase (μMol NADPH/gHb); ^*paired 𝑡-test.