Implication of DNA Methylation Profiling in Oral Epithelium for Lung Cancer Screening

Table 2

Frequency of promoter methylation in oral epithelium from lung cancer patients and controls.

Gene		Number (%)
Symbol	Description	Patients (𝑛=16)	Controls (𝑛=32)	𝑃
APC	Adenomatous polyposis coli	0 (0)	0 (0)	N/A
GDNF	Glial cell line-derived neurotrophic factor	7 (43.8)	2 (6.3)	0.0017
RARB	Retinoic acid receptor beta	6 (37.5)	2 (6.3)	0.0062
GSTP1	Glutathione S-transferase P 1	0 (0)	0 (0)	N/A
TIMP3	Tissue inhibitor of metalloproteinase-3	0 (0)	0 (0)	N/A
MGMT	O6-methylguanine-DNA methyltransferase	0 (0)	0 (0)	N/A
RASSF1A	Ras association domain family 1	0 (0)	0 (0)	N/A
MASPIN	Serpin peptidase inhibitor	16 (100)	32 (100)	N/A
CDH1	Cadherin 1	0 (0)	0 (0)	N/A
HS3ST2	Heparan sulfate 3-O-sulfotransferase 2	4 (25.0)	1 (3.1)	0.0193
CHARM1	Cholinergic receptor, muscarinic 1	15 (93.8)	28 (87.5)	n. s.