Implication of DNA Methylation Profiling in Oral Epithelium for Lung Cancer Screening

Table 4

Difference in the number of gene methylation sites (GDNF, RARB, and HS3ST2) according to total population and subgroup analysis.

		Number (%)
	Number of DNA methylation	Patients	Controls	𝑃
Total participants		16	32
	0-1	10 (62.5)	31 (96.9)	0.0015
	2-3	6 (37.5)	1 (3.1)
Current and former smokers		11	17
	0-1	8 (72.7)	16 (94.1)	0.1142
	2-3	3 (27.3)	1 (5.9)
Never smokers		5	15
	0-1	2 (40.0)	15 (100)	0.0011
	2-3	3 (60.0)	0 (0)
Age > 50 years		16	16
	0-1	9 (56.3)	15 (93.8)	0.0143
	2-3	7 (43.7)	1 (6.2)