Table of Contents
ISRN Pharmaceutics
Volume 2012, Article ID 976879, 7 pages
http://dx.doi.org/10.5402/2012/976879
Research Article

Biodegradable In Situ Gel-Forming Controlled Drug Delivery System Based on Thermosensitive Poly( -caprolactone)-Poly(ethylene glycol)-Poly( -caprolactone) Hydrogel

1Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Chemistry, Faculty of Science, Ferdowsi University, Mashhad, Iran
4Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Received 16 March 2012; Accepted 23 May 2012

Academic Editors: D. Kuzmich and C. Zacharis

Copyright © 2012 Elham Khodaverdi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Traditional drug delivery systems which are based on multiple dosing regimens usually pose many disadvantages such as poor compliance of patients and drug plasma level variation. To overcome the obstacles of traditional drug formulations, novel drug delivery system PCL-PEG-PCL hydrogels have been purposed in this study. Copolymers were synthesized by rapid microwave-assisted and conventional synthesis methods. Polymer characterizations were done using gel permeation chromatography and 1H-NMR. Phase transition behavior was evaluated by inverting tube method and in vitro drug release profile was determined using naltrexone hydrochloride and vitamin B12 as drug models. The results indicated that loaded drug structure and copolymer concentration play critical roles in release profile of drugs from these hydrogels. This study also confirmed that synthesis of copolymer using microwave is the most effective method for synthesis of this kind of copolymer.