| Input: patient record (P) and drug record (D) for user-selected drug |
| Output: user messages, calculated dose-response curves |
| (1) DI new DrugInteraction record (Figure 1) |
| (2) Mult, Dec, Inc 0 |
| (3) if no row exists in DrugEnzyme (DE) table where DE.Enzyme = D.Enzyme & DE.Drug = D.Drug then |
| (4) output “No Interaction Detected” |
| (5) else |
| (6) DI row from DrugInteraction table (DIT) where DIT.GenericName = D.GenericName & DIT.Form = |
| D.Form & DIT.Delivery = D.Delivery |
| (7) if DI.DrugMetabolite is not null then |
| (8) output “ProDrug Interaction Detected” |
| (9) else |
| (10) output “Interaction Detected” |
| (11) Mult Multiplier from DrugMultiplier (DM) where DM.Allele1 = P.Allele1 & DM.Allele2 = P.Allele2 & |
| DM.Drug = D.Drug {null if no match} |
| (12) if Mult is not null then |
| (13) Graph(DI, P.Weight, D.Dose, Mult) |
| (14) else if DI.PoorMetabolizerMultiplier is not null then |
| (15) Mult DI.PoorMetabolizerMultiplier |
| (16) Graph(DI, P.Weight, D.Dose, Mult) |
| (17) else |
| (18) for all alleles in Allele (A) that match patient’s alleles (P.Allele or P.Allele2) do |
| (19) if A.AlleleEffectInvivo = then |
| (20) Inc Inc + 1 |
| (21) else if A.AlleleEffectInvivo = then |
| (22) Dec Dec + 1 |
| (23) end if |
| (24) end for |
| (25) if Inc ≥ 1 or Dec ≥ 1 then |
| (26) Mult 1 + (Inc * 0.33) − (Dec * 0.33) |
| (27) Graph(DI, P.Weight, D.Dose, Mult) |
| (28) else |
| (29) output “Not Enough Information to Graph” |
| (30) end if |
| (31) end if |
| (32) end if |
| (33) end if |
