Construction of a Drug Safety Assurance Information System Based on Clinical Genotyping

Algorithm 3

CreateDoseCurve algorithm (X and Y refer to coordinates in curve).

Input: drug interaction record (DI), patient’s weight (Weight), drug dose (Dose), multiplier (Mult)

Output: a 2-dimensional curve

(1) k ←.693/DI.Halflife

(2) Calculate peak plasma concentration (PPC) using Dose, DI.Bioavailibility, DI.VolDistribution, Weight, 𝑘(1)

(3) if Mult ≠ 1 then

(4)  PPC ← PPC × Mult

(5)  DI.Halflife ← DI.Halflife × Mult

(6) end if

(7) Plot 1st part of curve using DI.PeakTime, PPC (Table 1)

(8) if Mult ≥ 1 then

(9)    Halflife5X ← last X + (DI.Halflife × 10)

(10) else

(11)  Halflife5X ← last X + ((DI.Halflife × 10)/Mult)

(12) end if

(13) while (X + (DrugInteraction.Halflife/5)) < Halflife5X do

(14)  X ←X + (DrugInteraction.Halflife/5); Y ←Y× 0.9

(15)  Add (X,Y) to curve

(16) end while

(17) return 2-dimensional curve